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Nature Made SAM-e Complete 400 mg supplement bottle
Nature Made

SAM-e Complete 400 mg Review

What We Researched
2 active ingredients analyzed · 10 inactive ingredients decoded · 5 brand certifications checked · Page generated: Sep 2026
96
Product Score Excellent
95
Brand Score Excellent

Two independent scores — the product and the brand behind it, never blended into one number. See our methodology.

Product Analysis

Transparency Excellent

Supplement Facts

IngredientAmount% DV
SAM-e 400 mg †
Bioavailability Excellent

Absorption Rating

  • SAM-e Good
Other Ingredients Very Good

Fillers & Additives

  • S-Adenosylmethionine Tosylate Disulfate
  • Cellulose Gel
  • Methacrylic Acid Copolymer
  • Stearic Acid
  • Silicon Dioxide
  • Triethyl Citrate
  • Magnesium Stearate
  • Color Added Medium
  • Mannitol
  • Sodium Starch Glycolate
Efficacy Excellent

Dosage Analysis

  • SAM-e 400 mg Effective

Supplement Facts

Ingredient Amount % Daily Value
Protein 1 g
SAM-e 400 mg †

Other Ingredients

Inactive ingredients used in manufacturing. All rated for safety.

S-Adenosylmethionine Tosylate Disulfate Unknown
Cellulose Gel Generally_safe

It is used as a thickening agent to improve the texture of supplements.

Methacrylic Acid Copolymer Generally_safe

It is added to provide a protective coating or to control the release of ingredients.

Stearic Acid Safe

Helps ingredients flow smoothly through manufacturing equipment.

Silicon Dioxide Safe

Prevents clumping and ensures consistent dosing.

Triethyl Citrate Generally_safe

It is used as a plasticizer or solvent.

Magnesium Stearate Safe

Prevents ingredients from sticking to manufacturing equipment during tableting.

Color Added Caution

It is used to improve the appearance of the supplement.

Mannitol Generally_safe

It is used as a sweetener, filler, and flow agent.

Sodium Starch Glycolate Safe

Helps tablets break apart quickly for faster absorption.

Brand Trust Report
Nature Made

Founded 1971 · West Hills, California, USA · 701 products · naturemade.com

Certifications

5 certifications
Consumerlab Source available Primary evidence
Labdoor Source available Primary evidence
Usp Verified Source available Primary evidence
Fda Gmp Inspections Source available Primary evidence
NSF Certified Supporting evidence unavailable

Transparency

5 claims
Third Party Testing Claim — Verified Evidence available Evidence
Coa Availability — Claimed Evidence available Evidence
In House Testing — Verified Evidence available Evidence
Testing Lab Disclosure — True Brand claim; evidence unavailable

Violation History

2 incidents
Lawsuit Presence of toxic plastic chemicals in prenatal multivitamins.2025 Source available Primary source
Recall Specific lots of Nature Made Adult Gummies Multi, Multi + Omega-3, Multi for Her plus Omega-3s, and Super B Complex w/C & Folic Acid2016-06-15 Source available Primary source
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Frequently Asked Questions
Is Nature Made SAM-e Complete 400 mg a good supplement?

Nature Made SAM-e Complete 400 mg received a product quality score of 96/100 in GoodSupp's independent analysis, placing it in the top tier of supplements we've analyzed. The product contains 2 active ingredients Of the 10 inactive ingredients, 8 are rated safe and 1 ingredient is flagged for review. The manufacturer, Nature Made, holds a brand trust score of 95/100.

What are the ingredients in Nature Made SAM-e Complete 400 mg?

Nature Made SAM-e Complete 400 mg contains 2 active ingredients: Protein (1 g), SAM-e (400 mg). Each ingredient's dosage, form, and safety rating is analyzed independently in GoodSupp's full product breakdown.

Is Nature Made SAM-e Complete 400 mg safe to take?

GoodSupp reviewed the inactive-ingredient data available for Nature Made SAM-e Complete 400 mg. Of 10 inactive ingredients, 8 are rated safe. 1 ingredient is flagged for review: Color Added. 'Caution' doesn't mean dangerous — it indicates the ingredient has some considerations worth being aware of, such as potential sensitivities or ongoing research. This label analysis cannot determine whether the product is safe for a particular person, and source labels may change. Always consult your healthcare provider before starting any new supplement, especially if you take medications or have underlying health conditions.

Is Nature Made a trustworthy supplement brand?

Nature Made receives a brand trust score of 95/100 based on GoodSupp's independent analysis of certifications, regulatory history, and transparency practices. Founded in 1971 and headquartered in West Hills, California, USA, the company offers 701 products in their lineup. Note: Nature Made has 2 historical regulatory incidents on record, which are factored into the trust score.

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Disclaimer: GoodSupp provides independent supplement quality analysis for informational purposes only. Scores are generated algorithmically based on ingredient profiles, brand certifications, and public records — read our methodology. This is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Product data is sourced from manufacturer labels and public databases. GoodSupp is not affiliated with any supplement brand.