Vitacost-Synergy SAM-e, 400 mg, 60 Enteric Coated Tabs supplement bottle
Vitacost-Synergy

SAM-e, 400 mg, 60 Enteric Coated Tabs

What We Researched
1 active ingredient analyzed · 11 inactive ingredients decoded · 1 brand certification checked · 1 retailer compared · Last updated: Mar 2026
62
Product Score Fair
62
Brand Score Fair

Product Analysis

Transparency Excellent

Supplement Facts

IngredientAmount% DV
S-Adenosyl Methionine (from 800 mg of SAM-e tosylate disulfate) 400 mg *
Bioavailability Fair

Absorption Rating

  • S-Adenosyl Methionine (from 800 mg of SAM-e tosylate disulfate) Fair
Other Ingredients Excellent

Fillers & Additives

  • Microcrystalline Cellulose
  • Mannitol
  • Methacrylic Acid Copolymer
  • Citric Acid
  • Silicon Dioxide
  • Stearic Acid
  • Hydroxypropyl Methylcellulose
  • Triacetin
  • Sodium Starch Glycolate
  • Modified Cellulose Gum
  • Riboflavin (Color)
Efficacy Very Poor

Dosage Analysis

  • S-Adenosyl Methionine (from 800 mg of SAM-e tosylate disulfate) 400 mg Under-dosed

Supplement Facts

Ingredient Amount % Daily Value
S-Adenosyl Methionine (from 800 mg of SAM-e tosylate disulfate) 400 mg *

Other Ingredients

Inactive ingredients used in manufacturing. All rated for safety.

Microcrystalline Cellulose Safe

Adds bulk to small-dose supplements to make tablets/capsules a manageable size.

Mannitol Generally_safe

It is used as a sweetener, filler, and flow agent.

Methacrylic Acid Copolymer Generally_safe

It is added to provide a protective coating or to control the release of ingredients.

Citric Acid Safe

Adds tartness and acts as a natural preservative. Also aids in ingredient stability.

Silicon Dioxide Safe

Prevents clumping and ensures consistent dosing.

Stearic Acid Safe

Helps ingredients flow smoothly through manufacturing equipment.

Hydroxypropyl Methylcellulose Safe

It is used as a coating for tablets and capsules.

Triacetin Generally_safe

It is used as a solvent or humectant.

Sodium Starch Glycolate Safe

Helps tablets break apart quickly for faster absorption.

Modified Cellulose Gum Generally_safe

It is used to improve the texture and stability of products.

Riboflavin (Color) Safe

It is used as a natural food coloring.

Price Comparison

Price History

Tracked across major retailers. Updated periodically.

$32$31$30$29$28 Mar 12 $29.99
Vitacost

Prices shown at time of last check. Click a retailer to see current price. GoodSupp is not affiliated with any retailer.

Brand Trust Report
Vitacost-Synergy

Founded 1994 · Boca Raton, Florida, United States · 53 products · vitacost.com/

Certifications

1 certification
Consumerlab Verified Source

Transparency

2 claims
Third Party Testing Claim — Claimed

Violation History

3 incidents
Prop 65 Lead2020-10-26Source
Lawsuit Mislabeled magnesium content in supplements.2016Source
Recall SYNERGY PLUS (For Children Over 4 Years) CHEWABLES Vitabots Multiple Vitamins & Minerals with Digestive Enzymes and Oat Bran1993-11-08Source
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Frequently Asked Questions
Is Vitacost-Synergy SAM-e, 400 mg a good supplement?

Vitacost-Synergy SAM-e, 400 mg, 60 Enteric Coated Tabs received a product quality score of 62/100 in GoodSupp's independent analysis, suggesting some areas that could be improved. The product contains 1 active ingredients with 60 servings per container. Of the 11 inactive ingredients, 7 are rated safe and 0 are flagged for review. The manufacturer, Vitacost-Synergy, holds a brand trust score of 62/100 with 1 verified certifications including Consumerlab.

What are the ingredients in Vitacost-Synergy SAM-e, 400 mg?

Vitacost-Synergy SAM-e, 400 mg contains 1 active ingredients: S-Adenosyl Methionine (from 800 mg of SAM-e tosylate disulfate) (400 mg). Each ingredient's dosage, form, and safety rating is analyzed independently in GoodSupp's full product breakdown.

Is Vitacost-Synergy SAM-e, 400 mg safe to take?

Vitacost-Synergy SAM-e, 400 mg, 60 Enteric Coated Tabs has been analyzed for ingredient safety across all its components. Always consult your healthcare provider before starting any new supplement, especially if you take medications or have underlying health conditions.

Is Vitacost-Synergy a trustworthy supplement brand?

Vitacost-Synergy receives a brand trust score of 62/100 based on GoodSupp's independent analysis of certifications, regulatory history, and transparency practices. Founded in 1994 and headquartered in Boca Raton, Florida, United States, the company offers 53 products in their lineup. They hold 1 verified certifications including Consumerlab. Third-party certifications are independently verified and indicate the brand meets specific quality, purity, and manufacturing standards. Note: Vitacost-Synergy has 3 historical regulatory incidents on record, which are factored into the trust score.

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Disclaimer: GoodSupp provides independent supplement quality analysis for informational purposes only. Scores are generated algorithmically based on ingredient profiles, brand certifications, and public records. This is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Product data is sourced from manufacturer labels and public databases. GoodSupp is not affiliated with any supplement brand.