Thorne Methyl-Guard® supplement bottle
Thorne

Methyl-Guard® Review

What We Researched
4 active ingredients analyzed · 5 inactive ingredients decoded · 10 brand certifications checked · Page generated: Sep 2026
93
Product Score Excellent
98
Brand Score Excellent

Two independent scores — the product and the brand behind it, never blended into one number. See our methodology.

Product Analysis

Transparency Excellent

Supplement Facts

IngredientAmount% DV
Vitamin B6 (as Pyridoxal 5'-Phosphate) 20.4 mg 1,200%
Folate (1.2 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 2 mg DFE 500%
Vitamin B12 (as Methylcobalamin) 1.2 mg 50,000%
Betaine Anhydrous (Trimethylglycine) 1.8 g *
Bioavailability Very Good

Absorption Rating

  • Vitamin B6 (as Pyridoxal 5'-Phosphate) Fair
  • Folate (1.2 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) Good
  • Vitamin B12 (as Methylcobalamin) Good
  • Betaine Anhydrous (Trimethylglycine) Good
Other Ingredients Excellent

Fillers & Additives

  • Calcium Laurate
  • Calcium Citrate
  • Hypromellose
  • Silica
  • Silicon Dioxide
Efficacy Very Good

Dosage Analysis

  • Vitamin B6 (as Pyridoxal 5'-Phosphate) 20.4 mg Effective
  • Folate (1.2 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 2 mg DFE High
  • Vitamin B12 (as Methylcobalamin) 1.2 mg High
  • Betaine Anhydrous (Trimethylglycine) 1.8 g Effective

Supplement Facts

Ingredient Amount % Daily Value
Vitamin B6 (as Pyridoxal 5'-Phosphate) 20.4 mg 1,200%
Folate (1.2 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 2 mg DFE 500%
Vitamin B12 (as Methylcobalamin) 1.2 mg 50,000%
Betaine Anhydrous (Trimethylglycine) 1.8 g *

Other Ingredients

Inactive ingredients used in manufacturing. All rated for safety.

Calcium Laurate Generally_safe

It helps to bind ingredients together and prevent separation.

Calcium Citrate Safe

It provides a source of calcium.

Hypromellose Safe

Forms vegetarian capsule shells. Dissolves easily in the stomach.

Silica Safe

Prevents ingredients from clumping and improves powder flow.

Silicon Dioxide Safe

Prevents clumping and ensures consistent dosing.

Brand Trust Report
Thorne

Founded 1984 · New York, NY, United States · 204 products · thorne.com

Certifications

10 certifications
Nsf Certified For Sport Source available Primary evidence
Nsf Gmp Source available Primary evidence
Fda Gmp Inspections Source available Primary evidence
NSF Certified for Sport Supporting evidence unavailable
NSF Contents Certified Supporting evidence unavailable
Informed Choice Supporting evidence unavailable
Informed Sport Supporting evidence unavailable
Eurofins Certified Supplement Supporting evidence unavailable
Eurofins Clean Sport Supporting evidence unavailable
NSF Certified Supporting evidence unavailable

Transparency

4 claims
Third Party Testing Claim — Verified Evidence available Evidence
Testing Lab Disclosure — Verified Evidence available Evidence
In House Testing — Verified Evidence available Evidence

Violation History

2 incidents
Recall Captomer, Captomer-2502014-06-12 Source available Primary source
Prop 65 Lead2013-12-13 Source available Primary source
Related Supplements
Frequently Asked Questions
Is Thorne Methyl-Guard® a good supplement?

Thorne Methyl-Guard® received a product quality score of 93/100 in GoodSupp's independent analysis, placing it in the top tier of supplements we've analyzed. The product contains 4 active ingredients with 60 servings per container. All 5 inactive ingredients (fillers, binders, capsule materials) are rated safe — a clean formulation with no flagged additives. The manufacturer, Thorne, holds a brand trust score of 98/100.

What are the ingredients in Thorne Methyl-Guard®?

Thorne Methyl-Guard® contains 4 active ingredients: Vitamin B6 (as Pyridoxal 5'-Phosphate) (20.4 mg), Folate (1.2 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) (2 mg DFE), Vitamin B12 (as Methylcobalamin) (1.2 mg), Betaine Anhydrous (Trimethylglycine) (1.8 g). Notable high-dose ingredients include Vitamin B6 at 1,200% DV, Folate at 500% DV, Vitamin B12 at 50,000% DV. Each ingredient's dosage, form, and safety rating is analyzed independently in GoodSupp's full product breakdown.

Is Thorne Methyl-Guard® safe to take?

GoodSupp reviewed the inactive-ingredient data available for Thorne Methyl-Guard®. All 5 inactive ingredients — including capsule materials, fillers, and binders — are currently classified as safe in GoodSupp's ingredient reference data. This label analysis cannot determine whether the product is safe for a particular person, and source labels may change. Always consult your healthcare provider before starting any new supplement, especially if you take medications or have underlying health conditions.

Is Thorne a trustworthy supplement brand?

Thorne receives a brand trust score of 98/100 based on GoodSupp's independent analysis of certifications, regulatory history, and transparency practices. Founded in 1984 and headquartered in New York, NY, United States, the company offers 204 products in their lineup. Note: Thorne has 2 historical regulatory incidents on record, which are factored into the trust score.

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Disclaimer: GoodSupp provides independent supplement quality analysis for informational purposes only. Scores are generated algorithmically based on ingredient profiles, brand certifications, and public records — read our methodology. This is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Product data is sourced from manufacturer labels and public databases. GoodSupp is not affiliated with any supplement brand.