Thorne Methyl-Guard® supplement bottle
Thorne

Methyl-Guard® Review

What We Researched
4 active ingredients analyzed · 5 inactive ingredients decoded · 10 brand certifications checked · Last updated: Aug 2026
93
Product Score Excellent
98
Brand Score Excellent

Two independent scores — the product and the brand behind it, never blended into one number. See our methodology.

Product Analysis

Transparency Excellent

Supplement Facts

IngredientAmount% DV
Vitamin B6 (as Pyridoxal 5'-Phosphate) 20.4 mg 1,200%
Folate (1.2 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 2 mg DFE 500%
Vitamin B12 (as Methylcobalamin) 1.2 mg 50,000%
Betaine Anhydrous (Trimethylglycine) 1.8 g *
Bioavailability Very Good

Absorption Rating

  • Vitamin B6 (as Pyridoxal 5'-Phosphate) Fair
  • Folate (1.2 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) Good
  • Vitamin B12 (as Methylcobalamin) Good
  • Betaine Anhydrous (Trimethylglycine) Good
Other Ingredients Excellent

Fillers & Additives

  • Calcium Laurate
  • Calcium Citrate
  • Hypromellose
  • Silica
  • Silicon Dioxide
Efficacy Very Good

Dosage Analysis

  • Vitamin B6 (as Pyridoxal 5'-Phosphate) 20.4 mg Effective
  • Folate (1.2 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 2 mg DFE High
  • Vitamin B12 (as Methylcobalamin) 1.2 mg High
  • Betaine Anhydrous (Trimethylglycine) 1.8 g Effective

Supplement Facts

Ingredient Amount % Daily Value
Vitamin B6 (as Pyridoxal 5'-Phosphate) 20.4 mg 1,200%
Folate (1.2 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 2 mg DFE 500%
Vitamin B12 (as Methylcobalamin) 1.2 mg 50,000%
Betaine Anhydrous (Trimethylglycine) 1.8 g *

Other Ingredients

Inactive ingredients used in manufacturing. All rated for safety.

Calcium Laurate Generally_safe

It helps to bind ingredients together and prevent separation.

Calcium Citrate Safe

It provides a source of calcium.

Hypromellose Safe

Forms vegetarian capsule shells. Dissolves easily in the stomach.

Silica Safe

Prevents ingredients from clumping and improves powder flow.

Silicon Dioxide Safe

Prevents clumping and ensures consistent dosing.

Brand Trust Report
Thorne

Founded 1984 · New York, NY, United States · 204 products · thorne.com

Certifications

10 certifications
Nsf Certified For Sport Verified Source
Nsf Gmp Verified Source
Fda Gmp Inspections Verified Source
NSF Certified for Sport Verified
NSF Contents Certified Verified
Informed Choice Verified
Informed Sport Verified
Eurofins Certified Supplement Verified
Eurofins Clean Sport Verified
NSF Certified Verified

Transparency

4 claims
Third Party Testing Claim — Verified Source
Testing Lab Disclosure — Verified Source
In House Testing — Verified Source

Violation History

2 incidents
Recall Captomer, Captomer-2502014-06-12Source
Prop 65 Lead2013-12-13Source
Related Supplements
Frequently Asked Questions
Is Thorne Methyl-Guard® a good supplement?

Thorne Methyl-Guard® received a product quality score of 93/100 in GoodSupp's independent analysis, placing it in the top tier of supplements we've analyzed. The product contains 4 active ingredients with 60 servings per container. Of the 5 inactive ingredients, 4 are rated safe and 0 are flagged for review. The manufacturer, Thorne, holds a brand trust score of 98/100 with 10 verified certifications including Nsf Certified For Sport, Nsf Gmp, Fda Gmp Inspections, NSF Certified for Sport.

What are the ingredients in Thorne Methyl-Guard®?

Thorne Methyl-Guard® contains 4 active ingredients: Vitamin B6 (as Pyridoxal 5'-Phosphate) (20.4 mg), Folate (1.2 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) (2 mg DFE), Vitamin B12 (as Methylcobalamin) (1.2 mg), Betaine Anhydrous (Trimethylglycine) (1.8 g). Notable high-dose ingredients include Vitamin B6 at 1,200% DV, Folate at 500% DV, Vitamin B12 at 50,000% DV. Each ingredient's dosage, form, and safety rating is analyzed independently in GoodSupp's full product breakdown.

Is Thorne Methyl-Guard® safe to take?

Thorne Methyl-Guard® has been analyzed for ingredient safety across all its components. Always consult your healthcare provider before starting any new supplement, especially if you take medications or have underlying health conditions.

Is Thorne a trustworthy supplement brand?

Thorne receives a brand trust score of 98/100 based on GoodSupp's independent analysis of certifications, regulatory history, and transparency practices. Founded in 1984 and headquartered in New York, NY, United States, the company offers 204 products in their lineup. They hold 10 verified certifications including Nsf Certified For Sport, Nsf Gmp, Fda Gmp Inspections, NSF Certified for Sport. Third-party certifications are independently verified and indicate the brand meets specific quality, purity, and manufacturing standards. Note: Thorne has 2 historical regulatory incidents on record, which are factored into the trust score.

Scan Any Supplement Instantly

Download GoodSupp to scan barcodes, check ingredient safety, and find the best supplements for your needs.

Disclaimer: GoodSupp provides independent supplement quality analysis for informational purposes only. Scores are generated algorithmically based on ingredient profiles, brand certifications, and public records — read our methodology. This is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Product data is sourced from manufacturer labels and public databases. GoodSupp is not affiliated with any supplement brand.