Thorne Methyl-Guard Plus® supplement bottle
Thorne

Methyl-Guard Plus® Review

What We Researched
5 active ingredients analyzed · 4 inactive ingredients decoded · 10 brand certifications checked · Last updated: Aug 2026
95
Product Score Excellent
98
Brand Score Excellent

Two independent scores — the product and the brand behind it, never blended into one number. See our methodology.

Product Analysis

Transparency Excellent

Supplement Facts

IngredientAmount% DV
Riboflavin (as Riboflavin 5'-Phosphate Sodium) 90 mg 6,923%
Vitamin B6 (as Pyridoxal 5'-Phosphate) 45 mg 2,647%
Folate (3 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 5 mg DFE 1,250%
Vitamin B12 (as Methylcobalamin) 3 mg 125,000%
Betaine Anhydrous (Trimethylglycine) 1.8 g *
Bioavailability Excellent

Absorption Rating

  • Riboflavin (as Riboflavin 5'-Phosphate Sodium) Good
  • Vitamin B6 (as Pyridoxal 5'-Phosphate) Fair
  • Folate (3 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) Good
  • Vitamin B12 (as Methylcobalamin) Good
  • Betaine Anhydrous (Trimethylglycine) Good
Other Ingredients Excellent

Fillers & Additives

  • Calcium Citrate
  • Calcium Laurate
  • Hypromellose
  • Vegetable Capsule
Efficacy Excellent

Dosage Analysis

  • Riboflavin (as Riboflavin 5'-Phosphate Sodium) 90 mg Effective
  • Vitamin B6 (as Pyridoxal 5'-Phosphate) 45 mg Effective
  • Folate (3 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 5 mg DFE High
  • Vitamin B12 (as Methylcobalamin) 3 mg High
  • Betaine Anhydrous (Trimethylglycine) 1.8 g Effective

Supplement Facts

Ingredient Amount % Daily Value
Riboflavin (as Riboflavin 5'-Phosphate Sodium) 90 mg 6,923%
Vitamin B6 (as Pyridoxal 5'-Phosphate) 45 mg 2,647%
Folate (3 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 5 mg DFE 1,250%
Vitamin B12 (as Methylcobalamin) 3 mg 125,000%
Betaine Anhydrous (Trimethylglycine) 1.8 g *

Other Ingredients

Inactive ingredients used in manufacturing. All rated for safety.

Calcium Citrate Safe

It provides a source of calcium.

Calcium Laurate Generally_safe

It helps to bind ingredients together and prevent separation.

Hypromellose Safe

Forms vegetarian capsule shells. Dissolves easily in the stomach.

Vegetable Capsule Safe

It is used as a vegetarian alternative to gelatin capsules.

Brand Trust Report
Thorne

Founded 1984 · New York, NY, United States · 204 products · thorne.com

Certifications

10 certifications
Nsf Certified For Sport Verified Source
Nsf Gmp Verified Source
Fda Gmp Inspections Verified Source
NSF Certified for Sport Verified
NSF Contents Certified Verified
Informed Choice Verified
Informed Sport Verified
Eurofins Certified Supplement Verified
Eurofins Clean Sport Verified
NSF Certified Verified

Transparency

4 claims
Third Party Testing Claim — Verified Source
Testing Lab Disclosure — Verified Source
In House Testing — Verified Source

Violation History

2 incidents
Recall Captomer, Captomer-2502014-06-12Source
Prop 65 Lead2013-12-13Source
Related Supplements
Frequently Asked Questions
Is Thorne Methyl-Guard Plus® a good supplement?

Thorne Methyl-Guard Plus® received a product quality score of 95/100 in GoodSupp's independent analysis, placing it in the top tier of supplements we've analyzed. The product contains 5 active ingredients with 30 servings per container. Of the 4 inactive ingredients, 3 are rated safe and 0 are flagged for review. The manufacturer, Thorne, holds a brand trust score of 98/100 with 10 verified certifications including Nsf Certified For Sport, Nsf Gmp, Fda Gmp Inspections, NSF Certified for Sport.

What are the ingredients in Thorne Methyl-Guard Plus®?

Thorne Methyl-Guard Plus® contains 5 active ingredients: Riboflavin (as Riboflavin 5'-Phosphate Sodium) (90 mg), Vitamin B6 (as Pyridoxal 5'-Phosphate) (45 mg), Folate (3 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) (5 mg DFE), Vitamin B12 (as Methylcobalamin) (3 mg), Betaine Anhydrous (Trimethylglycine) (1.8 g). Notable high-dose ingredients include Riboflavin at 6,923% DV, Vitamin B6 at 2,647% DV, Folate at 1,250% DV. Each ingredient's dosage, form, and safety rating is analyzed independently in GoodSupp's full product breakdown.

Is Thorne Methyl-Guard Plus® safe to take?

Thorne Methyl-Guard Plus® has been analyzed for ingredient safety across all its components. Always consult your healthcare provider before starting any new supplement, especially if you take medications or have underlying health conditions.

Is Thorne a trustworthy supplement brand?

Thorne receives a brand trust score of 98/100 based on GoodSupp's independent analysis of certifications, regulatory history, and transparency practices. Founded in 1984 and headquartered in New York, NY, United States, the company offers 204 products in their lineup. They hold 10 verified certifications including Nsf Certified For Sport, Nsf Gmp, Fda Gmp Inspections, NSF Certified for Sport. Third-party certifications are independently verified and indicate the brand meets specific quality, purity, and manufacturing standards. Note: Thorne has 2 historical regulatory incidents on record, which are factored into the trust score.

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Disclaimer: GoodSupp provides independent supplement quality analysis for informational purposes only. Scores are generated algorithmically based on ingredient profiles, brand certifications, and public records — read our methodology. This is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Product data is sourced from manufacturer labels and public databases. GoodSupp is not affiliated with any supplement brand.