Pure Encapsulations MethylAssist supplement bottle
Pure Encapsulations

MethylAssist Review

What We Researched
4 active ingredients analyzed · 2 inactive ingredients decoded · 4 brand certifications checked · Last updated: Aug 2026
95
Product Score Excellent
81
Brand Score Good

Two independent scores — the product and the brand behind it, never blended into one number. See our methodology.

Product Analysis

Transparency Excellent

Supplement Facts

IngredientAmount% DV
Vitamin B6 (as pyridoxal 5' phosphate)(activated B6) 16 mg 941%
Folate (as Metafolin®, L-5-MTHF) (1,000 mcg L-5-MTHF) 1,667 mcg DFE 417%
Vitamin B12 (as methylcobalamin) 1,000 mcg 41,667%
BenfoPure® benfotiamine 75 mg *
Bioavailability Very Good

Absorption Rating

  • Vitamin B6 (as pyridoxal 5' phosphate)(activated B6) Fair
  • Folate (as Metafolin®, L-5-MTHF) (1,000 mcg L-5-MTHF) Good
  • Vitamin B12 (as methylcobalamin) Good
  • BenfoPure® benfotiamine Good
Other Ingredients Excellent

Fillers & Additives

  • Hypoallergenic Plant Fiber
  • Vegetarian Capsule
Efficacy Excellent

Dosage Analysis

  • Vitamin B6 (as pyridoxal 5' phosphate)(activated B6) 16 mg Effective
  • Folate (as Metafolin®, L-5-MTHF) (1,000 mcg L-5-MTHF) 1,667 mcg DFE High
  • Vitamin B12 (as methylcobalamin) 1,000 mcg Effective
  • BenfoPure® benfotiamine 75 mg Effective

Supplement Facts

Ingredient Amount % Daily Value
Vitamin B6 (as pyridoxal 5' phosphate)(activated B6) 16 mg 941%
Folate (as Metafolin®, L-5-MTHF) (1,000 mcg L-5-MTHF) 1,667 mcg DFE 417%
Vitamin B12 (as methylcobalamin) 1,000 mcg 41,667%
BenfoPure® benfotiamine 75 mg *

Other Ingredients

Inactive ingredients used in manufacturing. All rated for safety.

Hypoallergenic Plant Fiber Unknown
Vegetarian Capsule Safe

It is used as a vegetarian capsule shell material.

Brand Trust Report
Pure Encapsulations

Founded 1991 · Sudbury, Massachusetts, United States · 228 products · pureencapsulations.com

Certifications

4 certifications
Fda Gmp Inspections Verified Source
Nsf Gmp Verified Source
NSF Certified Verified
Gluten-Free Certified Verified

Transparency

4 claims
Third Party Testing Claim — Verified Source
Testing Lab Disclosure — Verified Source
Contains Proprietary Blend — True
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Frequently Asked Questions
Is Pure Encapsulations MethylAssist a good supplement?

Pure Encapsulations MethylAssist received a product quality score of 95/100 in GoodSupp's independent analysis, placing it in the top tier of supplements we've analyzed. The product contains 4 active ingredients with 90 servings per container. Of the 2 inactive ingredients, 1 are rated safe and 0 are flagged for review. The manufacturer, Pure Encapsulations, holds a brand trust score of 81/100 with 4 verified certifications including Fda Gmp Inspections, Nsf Gmp, NSF Certified, Gluten-Free Certified.

What are the ingredients in Pure Encapsulations MethylAssist?

Pure Encapsulations MethylAssist contains 4 active ingredients: Vitamin B6 (as pyridoxal 5' phosphate)(activated B6) (16 mg), Folate (as Metafolin®, L-5-MTHF) (1,000 mcg L-5-MTHF) (1,667 mcg DFE), Vitamin B12 (as methylcobalamin) (1,000 mcg), BenfoPure® benfotiamine (75 mg). Notable high-dose ingredients include Vitamin B6 at 941% DV, Folate at 417% DV, Vitamin B12 at 41,667% DV. Each ingredient's dosage, form, and safety rating is analyzed independently in GoodSupp's full product breakdown.

Is Pure Encapsulations MethylAssist safe to take?

Pure Encapsulations MethylAssist has been analyzed for ingredient safety across all its components. Always consult your healthcare provider before starting any new supplement, especially if you take medications or have underlying health conditions.

Is Pure Encapsulations a trustworthy supplement brand?

Pure Encapsulations receives a brand trust score of 81/100 based on GoodSupp's independent analysis of certifications, regulatory history, and transparency practices. Founded in 1991 and headquartered in Sudbury, Massachusetts, United States, the company offers 228 products in their lineup. They hold 4 verified certifications including Fda Gmp Inspections, Nsf Gmp, NSF Certified, Gluten-Free Certified. Third-party certifications are independently verified and indicate the brand meets specific quality, purity, and manufacturing standards. No regulatory violations or FDA warning letters were found in our research.

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Disclaimer: GoodSupp provides independent supplement quality analysis for informational purposes only. Scores are generated algorithmically based on ingredient profiles, brand certifications, and public records — read our methodology. This is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Product data is sourced from manufacturer labels and public databases. GoodSupp is not affiliated with any supplement brand.