Nature Made SAM-e Complete®, 400 mg, 36 Enteric-Coated Tablets supplement bottle
Nature Made

SAM-e Complete®, 400 mg, 36 Enteric-Coated Tablets

What We Researched
2 active ingredients analyzed · 10 inactive ingredients decoded · 4 brand certifications checked · 2 retailers compared · Last updated: Mar 2026
58
Product Score Poor
86
Brand Score Good

Product Analysis

Transparency Excellent

Supplement Facts

IngredientAmount% DV
Protein less than 1 g
SAMe (S-adenosylmethionine) 400 mg *
Bioavailability Fair

Absorption Rating

  • Protein less than Fair
  • SAMe (S-adenosylmethionine) Fair
Other Ingredients Very Good

Fillers & Additives

  • S-adenosylmethionine tosylate disulfate
  • Cellulose Gel
  • Methacrylic Acid Copolymer
  • Stearic Acid
  • Silicon Dioxide
  • Triethyl Citrate
  • Magnesium Stearate
  • Color Added Medium
  • Mannitol
  • Sodium Starch Glycolate
Efficacy Very Poor

Dosage Analysis

  • SAMe (S-adenosylmethionine) 400 mg Under-dosed

Supplement Facts

Ingredient Amount % Daily Value
Protein less than 1 g
SAMe (S-adenosylmethionine) 400 mg *

Other Ingredients

Inactive ingredients used in manufacturing. All rated for safety.

S-adenosylmethionine tosylate disulfate Unknown
Cellulose Gel Generally_safe

It is used as a thickening agent to improve the texture of supplements.

Methacrylic Acid Copolymer Generally_safe

It is added to provide a protective coating or to control the release of ingredients.

Stearic Acid Safe

Helps ingredients flow smoothly through manufacturing equipment.

Silicon Dioxide Safe

Prevents clumping and ensures consistent dosing.

Triethyl Citrate Generally_safe

It is used as a plasticizer or solvent.

Magnesium Stearate Safe

Prevents ingredients from sticking to manufacturing equipment during tableting.

Color Added Caution

It is used to improve the appearance of the supplement.

Mannitol Generally_safe

It is used as a sweetener, filler, and flow agent.

Sodium Starch Glycolate Safe

Helps tablets break apart quickly for faster absorption.

Price Comparison

Price History

Tracked across major retailers. Updated periodically.

$50$49$48$47$46 Mar 12 $47.69
Vitacost

Prices shown at time of last check. Click a retailer to see current price. GoodSupp is not affiliated with any retailer.

Brand Trust Report
Nature Made

Founded 1971 · West Hills, California, USA · 161 products · naturemade.com

Certifications

4 certifications
Consumerlab Verified Source
Labdoor Verified Source
Usp Verified Verified Source
Fda Gmp Inspections Verified Source

Transparency

4 claims
Third Party Testing Claim — Verified Source
Coa Availability — Claimed Source
In House Testing — Verified Source

Violation History

2 incidents
Lawsuit Presence of toxic plastic chemicals in prenatal multivitamins.2025Source
Recall Specific lots of Nature Made Adult Gummies Multi, Multi + Omega-3, Multi for Her plus Omega-3s, and Super B Complex w/C & Folic Acid2016-06-15Source
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Frequently Asked Questions
Is Nature Made SAM-e Complete®, 400 mg a good supplement?

Nature Made SAM-e Complete®, 400 mg, 36 Enteric-Coated Tablets received a product quality score of 58/100 in GoodSupp's independent analysis, indicating several areas of concern that consumers should review. The product contains 2 active ingredients with 36 servings per container. Of the 10 inactive ingredients, 4 are rated safe and 1 are flagged for review. The manufacturer, Nature Made, holds a brand trust score of 86/100 with 4 verified certifications including Consumerlab, Labdoor, Usp Verified, Fda Gmp Inspections.

What are the ingredients in Nature Made SAM-e Complete®, 400 mg?

Nature Made SAM-e Complete®, 400 mg contains 2 active ingredients: Protein less than (1 g), SAMe (S-adenosylmethionine) (400 mg). Each ingredient's dosage, form, and safety rating is analyzed independently in GoodSupp's full product breakdown.

Is Nature Made SAM-e Complete®, 400 mg safe to take?

Nature Made SAM-e Complete®, 400 mg, 36 Enteric-Coated Tablets has been analyzed for ingredient safety across all its components. Of 10 inactive ingredients, 4 are rated safe. 1 ingredient is flagged for review: Color Added. 'Caution' doesn't mean dangerous — it indicates the ingredient has some considerations worth being aware of, such as potential sensitivities or ongoing research. Always consult your healthcare provider before starting any new supplement, especially if you take medications or have underlying health conditions.

Is Nature Made a trustworthy supplement brand?

Nature Made receives a brand trust score of 86/100 based on GoodSupp's independent analysis of certifications, regulatory history, and transparency practices. Founded in 1971 and headquartered in West Hills, California, USA, the company offers 161 products in their lineup. They hold 4 verified certifications including Consumerlab, Labdoor, Usp Verified, Fda Gmp Inspections. Third-party certifications are independently verified and indicate the brand meets specific quality, purity, and manufacturing standards. Note: Nature Made has 2 historical regulatory incidents on record, which are factored into the trust score.

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Disclaimer: GoodSupp provides independent supplement quality analysis for informational purposes only. Scores are generated algorithmically based on ingredient profiles, brand certifications, and public records. This is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Product data is sourced from manufacturer labels and public databases. GoodSupp is not affiliated with any supplement brand.