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Metagenics MethylCare supplement bottle
Metagenics

MethylCare Review

What We Researched
9 active ingredients analyzed · 5 inactive ingredients decoded · 8 brand certifications checked · Page generated: Sep 2026
85
Product Score Good
100
Brand Score Excellent

Two independent scores — the product and the brand behind it, never blended into one number. See our methodology.

Product Analysis

Transparency Excellent

Supplement Facts

IngredientAmount% DV
Riboflavin 1.6 mg 123%
Vitamin B6 (as Pyridoxine Hydrochloride) 25 mg 1471%
Metafolin (as Folate) 1330 mcg DFE 333%
Vitamin B12 (as Methylcobalamin) 1000 mcg 41667%
Zinc (as Zinc Citrate) 1.5 mg 14%
Manganese (as Manganese Citrate) 0.4 mg 17%
Molybdenum (as Molybdenum Glycinate) 15 mcg 33%
N-Acetyl-L-Cysteine 600 mg †
Betaine Hydrochloride 500 mg †
Bioavailability Very Good

Absorption Rating

  • Riboflavin Good
  • Vitamin B6 (as Pyridoxine Hydrochloride) Fair
  • Metafolin (as Folate) Fair
  • Vitamin B12 (as Methylcobalamin) Good
  • Zinc (as Zinc Citrate) Good
  • Manganese (as Manganese Citrate) Good
  • Molybdenum (as Molybdenum Glycinate) Good
  • N-Acetyl-L-Cysteine Good
  • Betaine Hydrochloride Good
Other Ingredients Excellent

Fillers & Additives

  • Hydroxypropyl Methylcellulose
  • Silicified Microcrystalline Cellulose
  • Stearic Acid
  • Magnesium Stearate
  • Silica
Efficacy Fair

Dosage Analysis

  • Riboflavin 1.6 mg Effective
  • Vitamin B6 (as Pyridoxine Hydrochloride) 25 mg Effective
  • Metafolin (as Folate) 1330 mcg DFE High
  • Vitamin B12 (as Methylcobalamin) 1000 mcg Effective
  • Zinc (as Zinc Citrate) 1.5 mg Under-dosed
  • Manganese (as Manganese Citrate) 0.4 mg Under-dosed
  • Molybdenum (as Molybdenum Glycinate) 15 mcg Under-dosed
  • N-Acetyl-L-Cysteine 600 mg Effective
  • Betaine Hydrochloride 500 mg Under-dosed

Supplement Facts

Ingredient Amount % Daily Value
Riboflavin 1.6 mg 123%
Vitamin B6 (as Pyridoxine Hydrochloride) 25 mg 1471%
Metafolin (as Folate) 1330 mcg DFE 333%
Vitamin B12 (as Methylcobalamin) 1000 mcg 41667%
Zinc (as Zinc Citrate) 1.5 mg 14%
Manganese (as Manganese Citrate) 0.4 mg 17%
Molybdenum (as Molybdenum Glycinate) 15 mcg 33%
N-Acetyl-L-Cysteine 600 mg †
Betaine Hydrochloride 500 mg †

Other Ingredients

Inactive ingredients used in manufacturing. All rated for safety.

Hydroxypropyl Methylcellulose Safe

It is used as a coating for tablets and capsules.

Silicified Microcrystalline Cellulose Generally_safe

It is used as a filler and flow agent in supplements.

Stearic Acid Safe

Helps ingredients flow smoothly through manufacturing equipment.

Magnesium Stearate Safe

Prevents ingredients from sticking to manufacturing equipment during tableting.

Silica Safe

Prevents ingredients from clumping and improves powder flow.

Brand Trust Report
Metagenics

Founded 1983 · Aliso Viejo, California, United States · 429 products · metagenics.com

Certifications

8 certifications
B Corp Certified Source available Primary evidence
Gluten Free Gfco Source available Primary evidence
Non Gmo Project Source available Primary evidence
Fda Gmp Inspections Source available Primary evidence
Nsf Gmp Source available Primary evidence
Usp Verified Source available Primary evidence
NSF Certified Supporting evidence unavailable
Gluten-Free Certified Supporting evidence unavailable

Transparency

6 claims
Third Party Testing Claim — Verified Evidence available Evidence
Coa Availability — Claimed Evidence available Evidence
In House Testing — Verified Evidence available Evidence
Testing Lab Disclosure — True Brand claim; evidence unavailable
Contains Proprietary Blend — True Brand claim; evidence unavailable

Violation History

3 incidents
Fda Warning A structure/function claim for 'Metagenics HerWellness Naturally Balanced' was deemed by the FDA to suggest the product is intended for use as a drug.2025-02-07 Source available Primary source
Prop 65 Lead2019-05-30 Source available Primary source
Fda Warning Mislabeling of 14 products as medical foods and making unapproved new drug claims.2013-08-13 Source available Primary source
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Frequently Asked Questions
Is Metagenics MethylCare a good supplement?

Metagenics MethylCare received a product quality score of 85/100 in GoodSupp's independent analysis, indicating strong overall quality. The product contains 9 active ingredients with 60 servings per container. All 5 inactive ingredients (fillers, binders, capsule materials) are rated safe — a clean formulation with no flagged additives. The manufacturer, Metagenics, holds a brand trust score of 100/100.

What are the ingredients in Metagenics MethylCare?

Metagenics MethylCare contains 9 active ingredients: Riboflavin (1.6 mg), Vitamin B6 (as Pyridoxine Hydrochloride) (25 mg), Metafolin (as Folate) (1330 mcg DFE), Vitamin B12 (as Methylcobalamin) (1000 mcg), Zinc (as Zinc Citrate) (1.5 mg), Manganese (as Manganese Citrate) (0.4 mg), and 3 more. Notable high-dose ingredients include Vitamin B6 at 1471% DV, Metafolin at 333% DV, Vitamin B12 at 41667% DV. Each ingredient's dosage, form, and safety rating is analyzed independently in GoodSupp's full product breakdown.

Is Metagenics MethylCare safe to take?

GoodSupp reviewed the inactive-ingredient data available for Metagenics MethylCare. All 5 inactive ingredients — including capsule materials, fillers, and binders — are currently classified as safe in GoodSupp's ingredient reference data. This label analysis cannot determine whether the product is safe for a particular person, and source labels may change. Always consult your healthcare provider before starting any new supplement, especially if you take medications or have underlying health conditions.

Is Metagenics a trustworthy supplement brand?

Metagenics receives a brand trust score of 100/100 based on GoodSupp's independent analysis of certifications, regulatory history, and transparency practices. Founded in 1983 and headquartered in Aliso Viejo, California, United States, the company offers 429 products in their lineup. Note: Metagenics has 3 historical regulatory incidents on record, which are factored into the trust score.

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Disclaimer: GoodSupp provides independent supplement quality analysis for informational purposes only. Scores are generated algorithmically based on ingredient profiles, brand certifications, and public records — read our methodology. This is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Product data is sourced from manufacturer labels and public databases. GoodSupp is not affiliated with any supplement brand.