Life Extension SAMe S-Adenosyl-Methionine, 400 mg, 60 Enteric Coated Vegetarian Tablets supplement bottle
Life Extension

SAMe S-Adenosyl-Methionine, 400 mg, 60 Enteric Coated Vegetarian Tablets

What We Researched
1 active ingredient analyzed · 12 inactive ingredients decoded · 3 brand certifications checked · 2 retailers compared · Last updated: Mar 2026
75
Product Score Fair
86
Brand Score Good

Product Analysis

Transparency Excellent

Supplement Facts

IngredientAmount% DV
S-Adenosyl-Methionine 400 mg **
Bioavailability Excellent

Absorption Rating

  • S-Adenosyl-Methionine Good
Other Ingredients Excellent

Fillers & Additives

  • Cellulose
  • Methacrylic Acid Copolymer
  • Mannitol
  • Citric Acid
  • Stearic Acid
  • Silica
  • Hypromellose
  • Glyceryl Triacetate
  • Sodium Starch Glycolate
  • Croscarmellose Sodium
  • Calcium Carbonate
  • Yellow ochre
Efficacy Very Poor

Dosage Analysis

  • S-Adenosyl-Methionine 400 mg Under-dosed

Supplement Facts

Ingredient Amount % Daily Value
S-Adenosyl-Methionine 400 mg **

Other Ingredients

Inactive ingredients used in manufacturing. All rated for safety.

Cellulose Safe

Provides bulk and structure in tablets and capsules.

Methacrylic Acid Copolymer Generally_safe

It is added to provide a protective coating or to control the release of ingredients.

Mannitol Generally_safe

It is used as a sweetener, filler, and flow agent.

Citric Acid Safe

Adds tartness and acts as a natural preservative. Also aids in ingredient stability.

Stearic Acid Safe

Helps ingredients flow smoothly through manufacturing equipment.

Silica Safe

Prevents ingredients from clumping and improves powder flow.

Hypromellose Safe

Forms vegetarian capsule shells. Dissolves easily in the stomach.

Glyceryl Triacetate Generally_safe

It is used as a solvent or to improve the texture of supplements.

Sodium Starch Glycolate Safe

Helps tablets break apart quickly for faster absorption.

Croscarmellose Sodium Safe

Helps tablets break apart and dissolve quickly in the stomach.

Calcium Carbonate Safe

Acts as a filler and provides supplemental calcium.

Yellow ochre Unknown

Price Comparison

iHerb $46.16
Best Price

Price History

Tracked across major retailers. Updated periodically.

$48$47$46$45$44 Mar 12 $46.00
iHerb

Prices shown at time of last check. Click a retailer to see current price. GoodSupp is not affiliated with any retailer.

Brand Trust Report
Life Extension

Founded 1980 · Fort Lauderdale, Florida, USA · 352 products · lifeextension.com

Certifications

3 certifications
Consumerlab Verified Source
Fda Gmp Inspections Verified Source
Nsf Gmp Verified Source

Transparency

4 claims
Third Party Testing Claim — Verified Source
Coa Availability — Verified Source
Testing Lab Disclosure — Claimed

Violation History

2 incidents
Prop 65 Lead2018-04-13Source
Fda Warning Making drug claims for dietary supplements, suggesting they can treat, mitigate, or prevent diseases such as breast cancer and Alzheimer's.2017-02-01Source
Related Supplements
NOW Foods Eggshell Membrane, 500 mg, 60 Capsules
NOW Foods Eggshell Membrane, 500 mg, 60 Capsules
Product 100 Brand 100
NOW Foods Sports, D-Ribose Powder, 1 lb (454 g)
NOW Foods Sports, D-Ribose Powder, 1 lb (454 g)
Product 100 Brand 100
NOW Foods Sports, D-Ribose Powder, 8 oz (227 g)
NOW Foods Sports, D-Ribose Powder, 8 oz (227 g)
Product 100 Brand 100
Life Extension Optimized Saffron with Satiereal
Life Extension Optimized Saffron with Satiereal
Product 100 Brand 86
Life Extension Bifido GI Balance, 60 Vegetarian Capsules
Life Extension Bifido GI Balance, 60 Vegetarian Capsules
Product 100 Brand 86
Life Extension PQQ, 20 mg, 30 Vegetarian Capsules
Life Extension PQQ, 20 mg, 30 Vegetarian Capsules
Product 100 Brand 86
Frequently Asked Questions
Is Life Extension SAMe S-Adenosyl-Methionine, 400 mg a good supplement?

Life Extension SAMe S-Adenosyl-Methionine, 400 mg, 60 Enteric Coated Vegetarian Tablets received a product quality score of 75/100 in GoodSupp's independent analysis, suggesting some areas that could be improved. The product contains 1 active ingredients Of the 12 inactive ingredients, 8 are rated safe and 0 are flagged for review. The manufacturer, Life Extension, holds a brand trust score of 86/100 with 3 verified certifications including Consumerlab, Fda Gmp Inspections, Nsf Gmp.

What are the ingredients in Life Extension SAMe S-Adenosyl-Methionine, 400 mg?

Life Extension SAMe S-Adenosyl-Methionine, 400 mg contains 1 active ingredients: S-Adenosyl-Methionine (400 mg). Each ingredient's dosage, form, and safety rating is analyzed independently in GoodSupp's full product breakdown.

Is Life Extension SAMe S-Adenosyl-Methionine, 400 mg safe to take?

Life Extension SAMe S-Adenosyl-Methionine, 400 mg, 60 Enteric Coated Vegetarian Tablets has been analyzed for ingredient safety across all its components. Always consult your healthcare provider before starting any new supplement, especially if you take medications or have underlying health conditions.

Is Life Extension a trustworthy supplement brand?

Life Extension receives a brand trust score of 86/100 based on GoodSupp's independent analysis of certifications, regulatory history, and transparency practices. Founded in 1980 and headquartered in Fort Lauderdale, Florida, USA, the company offers 352 products in their lineup. They hold 3 verified certifications including Consumerlab, Fda Gmp Inspections, Nsf Gmp. Third-party certifications are independently verified and indicate the brand meets specific quality, purity, and manufacturing standards. Note: Life Extension has 2 historical regulatory incidents on record, which are factored into the trust score.

Scan Any Supplement Instantly

Download GoodSupp to scan barcodes, check ingredient safety, and find the best supplements for your needs.

Download on App Store Browse All Supplements
Disclaimer: GoodSupp provides independent supplement quality analysis for informational purposes only. Scores are generated algorithmically based on ingredient profiles, brand certifications, and public records. This is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Product data is sourced from manufacturer labels and public databases. GoodSupp is not affiliated with any supplement brand.