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21st Century Berberine HCI 500 mg Vegetarian Capsules supplement bottle
21st Century

Berberine HCI 500 mg Vegetarian Capsules Review

What We Researched
1 active ingredient analyzed · 4 inactive ingredients decoded · 3 brand certifications checked · Page generated: Sep 2026
100
Product Score Excellent
85
Brand Score Good

Two independent scores — the product and the brand behind it, never blended into one number. See our methodology.

Product Analysis

Transparency Excellent

Supplement Facts

IngredientAmount% DV
Berberine HCI(Berberis aristata) (root) 1000 mg **
Bioavailability N/A

Absorption Rating

No ingredient forms matched our reference database.

Other Ingredients Excellent

Fillers & Additives

  • Vegetable Cellulose
  • Magnesium Stearate
  • Magnesium Silicate
  • Silicon Dioxide
Efficacy Excellent

Dosage Analysis

  • Berberine HCI(Berberis aristata) (root) 1000 mg Effective

Supplement Facts

Ingredient Amount % Daily Value
Berberine HCI(Berberis aristata) (root) 1000 mg **

Other Ingredients

Inactive ingredients used in manufacturing. All rated for safety.

Vegetable Cellulose Safe

Forms a vegetarian capsule shell alternative to gelatin.

Magnesium Stearate Safe

Prevents ingredients from sticking to manufacturing equipment during tableting.

Magnesium Silicate Generally_safe

It is used to improve powder flow and prevent clumping.

Silicon Dioxide Safe

Prevents clumping and ensures consistent dosing.

Brand Trust Report
21st Century

Founded 1991 · Tempe, Arizona, United States · 383 products · 21stcenturyvitamins.com/

Certifications

3 certifications
Nsf Gmp Source available Primary evidence
NSF Contents Certified Supporting evidence unavailable
NSF Certified Supporting evidence unavailable

Transparency

5 claims
Third Party Testing Claim — Claimed Evidence available Evidence
Testing Lab Disclosure — Verified Evidence available Evidence
In House Testing — Verified Evidence available Evidence
Contains Proprietary Blend — True Brand claim; evidence unavailable

Violation History

4 incidents
Prop 65 Lead2021-06-22 Source available Primary source
Recall Vitamin D3 5000 IU Tablets2021-05-19 Source available Primary source
Lawsuit False advertising of Glucosamine/Chondroitin supplements.2012 Source available Primary source
Prop 65 Lead2008-12-23 Source available Primary source
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Frequently Asked Questions
Is 21st Century Berberine HCI 500 mg Vegetarian Capsules a good supplement?

21st Century Berberine HCI 500 mg Vegetarian Capsules received a product quality score of 100/100 in GoodSupp's independent analysis, placing it in the top tier of supplements we've analyzed. The product contains 1 active ingredients with 30 servings per container. All 4 inactive ingredients (fillers, binders, capsule materials) are rated safe — a clean formulation with no flagged additives. The manufacturer, 21st Century, holds a brand trust score of 85/100.

What are the ingredients in 21st Century Berberine HCI 500 mg Vegetarian Capsules?

21st Century Berberine HCI 500 mg Vegetarian Capsules contains 1 active ingredients: Berberine HCI(Berberis aristata) (root) (1000 mg). Each ingredient's dosage, form, and safety rating is analyzed independently in GoodSupp's full product breakdown.

Is 21st Century Berberine HCI 500 mg Vegetarian Capsules safe to take?

GoodSupp reviewed the inactive-ingredient data available for 21st Century Berberine HCI 500 mg Vegetarian Capsules. All 4 inactive ingredients — including capsule materials, fillers, and binders — are currently classified as safe in GoodSupp's ingredient reference data. This label analysis cannot determine whether the product is safe for a particular person, and source labels may change. Always consult your healthcare provider before starting any new supplement, especially if you take medications or have underlying health conditions.

Is 21st Century a trustworthy supplement brand?

21st Century receives a brand trust score of 85/100 based on GoodSupp's independent analysis of certifications, regulatory history, and transparency practices. Founded in 1991 and headquartered in Tempe, Arizona, United States, the company offers 383 products in their lineup. Note: 21st Century has 4 historical regulatory incidents on record, which are factored into the trust score.

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Disclaimer: GoodSupp provides independent supplement quality analysis for informational purposes only. Scores are generated algorithmically based on ingredient profiles, brand certifications, and public records — read our methodology. This is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Product data is sourced from manufacturer labels and public databases. GoodSupp is not affiliated with any supplement brand.