Polyplasdone

Generally Safe BinderSynthetic

Polyplasdone is a synthetic binder used in dietary supplements. Safety rating: Generally Safe. It is generally considered safe for most people at standard doses. Found in 19 supplements in the GoodSupp database. A synthetic polymer used as a binder and disintegrant.

19 Products use this
Generally Safe Safety rating
Binder Category
No Natural origin

Safety Verdict: Generally Safe

This ingredient is rated generally safe for use in dietary supplements.

What is Polyplasdone?

A synthetic polymer used as a binder and disintegrant.

Common Names Polyplasdone, Crospovidone
Type Binder
Origin Synthetic / Manufactured
Safety Rating Generally Safe

Why is Polyplasdone used in supplements?

It is used to help tablets and capsules break down in the body.

Role in supplements: Binder — holds tablet ingredients together so they don't crumble.

Should you be concerned about Polyplasdone?

Generally no. Polyplasdone is considered safe for most people at typical supplement doses. Some individuals may want to be aware of minor sensitivities.

Low risk. Generally safe for most people in supplement amounts.

Top-rated products containing Polyplasdone

These 19 highest-scoring supplements in our database use Polyplasdone.

21st Century Melatonin, Quick Dissolve, Cherry, 10 mg, 360 Tablets
21st Century Melatonin, Quick Dissolve, Cherry, 10 mg, 360 Tablets
Product 87 Brand N/A
21st Century Zoo Friends Sleep, Children's Chewable Melatonin, Ages 4+, Raspberry, 60 Chewable Tablets
21st Century Zoo Friends Sleep, Children's Chewable Melatonin, Ages 4+, Raspberry, 60 Chewable Tablets
Product 87 Brand N/A
21st Century Melatonin, Quick Dissolve, Cherry, 10 mg, 120 Tablets
21st Century Melatonin, Quick Dissolve, Cherry, 10 mg, 120 Tablets
Product 87 Brand N/A
21st Century Glucosamine Chondroitin, Triple Strength, 150 Tablets
21st Century Glucosamine Chondroitin, Triple Strength, 150 Tablets
Product 86 Brand N/A
21st Century Glucosamine/Chondroitin, 60 Tablets
21st Century Glucosamine/Chondroitin, 60 Tablets
Product 86 Brand N/A
21st Century Vitamin B-12, Cherry, 2,500 mcg, 110 Tablets
21st Century Vitamin B-12, Cherry, 2,500 mcg, 110 Tablets
Product 81 Brand N/A
21st Century Vitamin B-12, Cherry, 5,000 mcg, 110 Sublingual Tablets
21st Century Vitamin B-12, Cherry, 5,000 mcg, 110 Sublingual Tablets
Product 81 Brand N/A
21st Century Melatonin, Max Strength, Cherry, 12 mg, 120 Tablets
21st Century Melatonin, Max Strength, Cherry, 12 mg, 120 Tablets
Product 81 Brand N/A
21st Century Arthri-Flex Advantage® + Vitamin D3, 120 Coated Tablets
21st Century Arthri-Flex Advantage® + Vitamin D3, 120 Coated Tablets
Product 78 Brand N/A
21st Century Glucosamine & Chondroitin plus Hyaluronic Acid + MSM, 120 Tablets
21st Century Glucosamine & Chondroitin plus Hyaluronic Acid + MSM, 120 Tablets
Product 71 Brand N/A
21st Century Glucosamine Chondroitin, 180 Tablets
21st Century Glucosamine Chondroitin, 180 Tablets
Product 68 Brand N/A
21st Century Chewable Vitamin D3, Orange, 10 mcg (400 IU), 110 Tablets
21st Century Chewable Vitamin D3, Orange, 10 mcg (400 IU), 110 Tablets
Product 62 Brand N/A
21st Century Zoo Friends, Children's Chewable Probiotic, Age 4+, Fruit Punch, 30 Chewable Tablets
21st Century Zoo Friends, Children's Chewable Probiotic, Age 4+, Fruit Punch, 30 Chewable Tablets
Product 57 Brand N/A
21st Century Glucosamine Chondroitin Complex Plus MSM, Advanced Triple Strength, 80 Tablets
21st Century Glucosamine Chondroitin Complex Plus MSM, Advanced Triple Strength, 80 Tablets
Product 56 Brand N/A
21st Century Glucosamine Chondroitin Complex Plus MSM, Advanced Triple Strength, 120 Coated Tablets
21st Century Glucosamine Chondroitin Complex Plus MSM, Advanced Triple Strength, 120 Coated Tablets
Product 55 Brand N/A
21st Century Glucosamine Relief®, 120 Tablets
21st Century Glucosamine Relief®, 120 Tablets
Product 52 Brand N/A
21st Century Glucosamine Chondroitin Advanced, 120 Coated Tablets
21st Century Glucosamine Chondroitin Advanced, 120 Coated Tablets
Product 51 Brand N/A
Leader Glucosamine Chondroitin Dietary Joint Support Supplement for Mobility and
Leader Glucosamine Chondroitin Dietary Joint Support Supplement for Mobility and
Product 51 Brand N/A
Rugby Cerovite Jr Children’s Chewable Multivitamin Tablets for Daily Nutrition and
Rugby Cerovite Jr Children’s Chewable Multivitamin Tablets for Daily Nutrition and
Product 49 Brand N/A
Related Ingredients
Acacia Generally Safe Acacia Gum Safe Croscarmellose Generally Safe Croscarmellose Sodium Safe Crospovidone Generally Safe Gum Acacia^ Generally Safe Hydrogenated Polyisobutene Generally Safe Hydroxypropyl Cellulose Safe
Frequently Asked Questions
Is Polyplasdone safe in supplements?

Polyplasdone is rated generally safe for most people at amounts commonly found in supplements. While the overall safety profile is favorable, some individuals may experience minor sensitivities. In GoodSupp's database, 19 products contain this ingredient. Consult your healthcare provider if you have specific concerns.

What is Polyplasdone and why is it in my supplement?

A synthetic polymer used as a binder and disintegrant. As a binder, it holds tablet ingredients together so they maintain their shape and don't crumble during handling. It appears in 19 products in the GoodSupp database.

Is Polyplasdone natural or synthetic?

Polyplasdone is synthetically produced, meaning it is manufactured through chemical processes rather than directly extracted from natural sources. Synthetic ingredients are extremely common in supplements and are not inherently less safe than natural alternatives. In many cases, synthetic production allows for higher purity and more consistent quality. The FDA regulates both natural and synthetic supplement ingredients under the same safety standards. GoodSupp rates ingredients based on their actual safety data regardless of whether they're natural or synthetic.

Check Any Supplement's Ingredients

Scan a barcode with GoodSupp to instantly see safety ratings for every ingredient.

Download on App Store
Disclaimer: GoodSupp provides independent supplement quality analysis for informational purposes only. Scores are generated algorithmically based on ingredient profiles, brand certifications, and public records. This is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Product data is sourced from manufacturer labels and public databases. GoodSupp is not affiliated with any supplement brand.