Hydroxypropylcellulose

Generally Safe BinderSynthetic

Hydroxypropylcellulose is a synthetic binder used in dietary supplements. Safety rating: Generally Safe. It is generally considered safe for most people at standard doses. Found in 20 supplements in the GoodSupp database. Hydroxypropylcellulose is a cellulose derivative used as a binder and film-forming agent.

20 Products use this
Generally Safe Safety rating
Binder Category
No Natural origin

Safety Verdict: Generally Safe

This ingredient is rated generally safe for use in dietary supplements.

What is Hydroxypropylcellulose?

Hydroxypropylcellulose is a cellulose derivative used as a binder and film-forming agent.

Common Names Hydroxypropylcellulose, HPC
Type Binder
Origin Synthetic / Manufactured
Safety Rating Generally Safe

Why is Hydroxypropylcellulose used in supplements?

It is added to bind ingredients together and provide a smooth coating.

Role in supplements: Binder — holds tablet ingredients together so they don't crumble.

Should you be concerned about Hydroxypropylcellulose?

Generally no. Hydroxypropylcellulose is considered safe for most people at typical supplement doses. Some individuals may want to be aware of minor sensitivities.

Low risk. Generally safe for most people in supplement amounts.

Top-rated products containing Hydroxypropylcellulose

These 20 highest-scoring supplements in our database use Hydroxypropylcellulose.

Kyolic Aged Garlic Extract, Cardiovascular Health, One Per Day, Formula 250, 60 Vegan Caplets (1,000 mg per Capsule)
Kyolic Aged Garlic Extract, Cardiovascular Health, One Per Day, Formula 250, 60 Vegan Caplets (1,000 mg per Capsule)
Product 100 Brand N/A
GNC Herbal Plus Grape Seed Extract 500 mg
GNC Herbal Plus Grape Seed Extract 500 mg
Product 100 Brand N/A
Natural Factors NEM, Knee & Joint Formula with Glucosamine, 60 Tablets
Natural Factors NEM, Knee & Joint Formula with Glucosamine, 60 Tablets
Product 100 Brand N/A
GNC SuperFoods Soy Isoflavone Concentrate 50 mg
GNC SuperFoods Soy Isoflavone Concentrate 50 mg
Product 100 Brand N/A
Webber Naturals Webber Naturals® Vitamin C Chewable, Natural Orange, 500 mg, 120 Chewable Tablets
Webber Naturals Webber Naturals® Vitamin C Chewable, Natural Orange, 500 mg, 120 Chewable Tablets
Product 100 Brand N/A
Equate Equate Vitamin C 500mg Orange Chewables, 150 Tablets
Equate Equate Vitamin C 500mg Orange Chewables, 150 Tablets
Product 100 Brand N/A
Equate Equate Vitamin D 1000IU Natural Orange Flavour, 180 Tablets
Equate Equate Vitamin D 1000IU Natural Orange Flavour, 180 Tablets
Product 100 Brand N/A
Spring Valley Spring Valley Vitamin C 500mg Chewable Tangy Orange flavour - VALUE SIZE, 350 Tablets
Spring Valley Spring Valley Vitamin C 500mg Chewable Tangy Orange flavour - VALUE SIZE, 350 Tablets
Product 100 Brand N/A
Spring Valley Spring Valley Vitamin C 500mg, 150 tablets
Spring Valley Spring Valley Vitamin C 500mg, 150 tablets
Product 100 Brand N/A
Equate Equate Vitamin C 500mg Tangy Orange Flavour
Equate Equate Vitamin C 500mg Tangy Orange Flavour
Product 100 Brand N/A
Equate Equate Vitamin C 500mg Multi-Fruit Flavour
Equate Equate Vitamin C 500mg Multi-Fruit Flavour
Product 100 Brand N/A
Maplelife Maplelife Nutrition® - Vitamin D3 1000 IU - Strong Bone and Teeth Support - 100 Tablets
Maplelife Maplelife Nutrition® - Vitamin D3 1000 IU - Strong Bone and Teeth Support - 100 Tablets
Product 100 Brand N/A
Kyolic Cardiovascular
Kyolic Cardiovascular
Product 100 Brand N/A
ProHealth Longevity NMN Pro 250, 250 mg, 60 Tablets
ProHealth Longevity NMN Pro 250, 250 mg, 60 Tablets
Product 93 Brand N/A
Source Naturals Top 10 Healers™, 30 Tablets
Source Naturals Top 10 Healers™, 30 Tablets
Product 93 Brand N/A
Source Naturals Top 10 Healers™, 60 Tablets
Source Naturals Top 10 Healers™, 60 Tablets
Product 93 Brand N/A
Carlson Niacin-Time 500 mg
Carlson Niacin-Time 500 mg
Product 93 Brand N/A
Webber Naturals Webber Naturals® B 100 Complex Time Release, Supports energy metabolism, 140 Tablets
Webber Naturals Webber Naturals® B 100 Complex Time Release, Supports energy metabolism, 140 Tablets
Product 88 Brand N/A
Life Extension Melatonin, 6 Hour Timed Release, 3 mg, 60 Vegetarian Tablets
Life Extension Melatonin, 6 Hour Timed Release, 3 mg, 60 Vegetarian Tablets
Product 87 Brand N/A
GNC Gentlesorb Iron 18 mg
GNC Gentlesorb Iron 18 mg
Product 87 Brand N/A
Related Ingredients
Acacia Generally Safe Acacia Gum Safe Croscarmellose Generally Safe Croscarmellose Sodium Safe Crospovidone Generally Safe Gum Acacia^ Generally Safe Hydrogenated Polyisobutene Generally Safe Hydroxypropyl Cellulose Safe
Frequently Asked Questions
Is Hydroxypropylcellulose safe in supplements?

Hydroxypropylcellulose is rated generally safe for most people at amounts commonly found in supplements. While the overall safety profile is favorable, some individuals may experience minor sensitivities. In GoodSupp's database, 20 products contain this ingredient. Consult your healthcare provider if you have specific concerns.

What is Hydroxypropylcellulose and why is it in my supplement?

Hydroxypropylcellulose is a cellulose derivative used as a binder and film-forming agent. As a binder, it holds tablet ingredients together so they maintain their shape and don't crumble during handling. It appears in 20 products in the GoodSupp database.

Is Hydroxypropylcellulose natural or synthetic?

Hydroxypropylcellulose is synthetically produced, meaning it is manufactured through chemical processes rather than directly extracted from natural sources. Synthetic ingredients are extremely common in supplements and are not inherently less safe than natural alternatives. In many cases, synthetic production allows for higher purity and more consistent quality. The FDA regulates both natural and synthetic supplement ingredients under the same safety standards. GoodSupp rates ingredients based on their actual safety data regardless of whether they're natural or synthetic.

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Disclaimer: GoodSupp provides independent supplement quality analysis for informational purposes only. Scores are generated algorithmically based on ingredient profiles, brand certifications, and public records. This is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Product data is sourced from manufacturer labels and public databases. GoodSupp is not affiliated with any supplement brand.