Thorne Methyl-Guard®, 180 Capsules supplement bottle
Thorne

Methyl-Guard®, 180 Capsules

What We Researched
4 active ingredients analyzed · 4 inactive ingredients decoded · 4 brand certifications checked · 4 retailers compared · Last updated: Mar 2026
93
Product Score Excellent
90
Brand Score Excellent

Product Analysis

Transparency Excellent

Supplement Facts

IngredientAmount% DV
Vitamin B6 (as Pyridoxal 5'-Phosphate) 20.4 mg 1,200%
Folate (1.2 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 2 mg DFE 500%
Vitamin B12 (as Methylcobalamin) 1.2 mg 50,000%
Betaine Anhydrous (Trimethylglycine) 1.8 g *
Bioavailability Very Good

Absorption Rating

  • Vitamin B6 (as Pyridoxal 5'-Phosphate) Fair
  • Folate (1.2 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) Good
  • Vitamin B12 (as Methylcobalamin) Good
  • Betaine Anhydrous (Trimethylglycine) Good
Other Ingredients Excellent

Fillers & Additives

  • Hypromellose (Derived from Cellulose) Capsule
  • Silicon Dioxide
  • Calcium Citrate
  • Calcium Laurate
Efficacy Very Good

Dosage Analysis

  • Vitamin B6 (as Pyridoxal 5'-Phosphate) 20.4 mg Effective
  • Folate (1.2 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 2 mg DFE High
  • Vitamin B12 (as Methylcobalamin) 1.2 mg High
  • Betaine Anhydrous (Trimethylglycine) 1.8 g Effective

Supplement Facts

Ingredient Amount % Daily Value
Vitamin B6 (as Pyridoxal 5'-Phosphate) 20.4 mg 1,200%
Folate (1.2 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 2 mg DFE 500%
Vitamin B12 (as Methylcobalamin) 1.2 mg 50,000%
Betaine Anhydrous (Trimethylglycine) 1.8 g *

Other Ingredients

Inactive ingredients used in manufacturing. All rated for safety.

Hypromellose (Derived from Cellulose) Capsule Safe

It is used to encapsulate supplement ingredients.

Silicon Dioxide Safe

Prevents clumping and ensures consistent dosing.

Calcium Citrate Safe

It provides a source of calcium.

Calcium Laurate Generally_safe

It helps to bind ingredients together and prevent separation.

Price Comparison

Price History

Tracked across major retailers. Updated periodically.

$58$57$56$55$54 Mar 12 $56.00$56.00
iHerb
Vitacost

Prices shown at time of last check. Click a retailer to see current price. GoodSupp is not affiliated with any retailer.

Brand Trust Report
Thorne

Founded 1984 · New York, NY, United States · 161 products · thorne.com

Certifications

4 certifications
Consumerlab Verified
Nsf Certified For Sport Verified Source
Nsf Gmp Verified Source
Fda Gmp Inspections Verified Source

Transparency

4 claims
Third Party Testing Claim — Verified Source
Testing Lab Disclosure — Verified Source
In House Testing — Verified Source

Violation History

2 incidents
Recall Captomer, Captomer-2502014-06-12Source
Prop 65 Lead2013-12-13Source
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Frequently Asked Questions
Is Thorne Methyl-Guard®, 180 Capsules a good supplement?

Thorne Methyl-Guard®, 180 Capsules received a product quality score of 93/100 in GoodSupp's independent analysis, placing it in the top tier of supplements we've analyzed. The product contains 4 active ingredients with 60 servings per container. Of the 4 inactive ingredients, 3 are rated safe and 0 are flagged for review. The manufacturer, Thorne, holds a brand trust score of 90/100 with 4 verified certifications including Consumerlab, Nsf Certified For Sport, Nsf Gmp, Fda Gmp Inspections.

What are the ingredients in Thorne Methyl-Guard®, 180 Capsules?

Thorne Methyl-Guard®, 180 Capsules contains 4 active ingredients: Vitamin B6 (as Pyridoxal 5'-Phosphate) (20.4 mg), Folate (1.2 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) (2 mg DFE), Vitamin B12 (as Methylcobalamin) (1.2 mg), Betaine Anhydrous (Trimethylglycine) (1.8 g). Notable high-dose ingredients include Vitamin B6 at 1,200% DV, Folate at 500% DV, Vitamin B12 at 50,000% DV. Each ingredient's dosage, form, and safety rating is analyzed independently in GoodSupp's full product breakdown.

Is Thorne Methyl-Guard®, 180 Capsules safe to take?

Thorne Methyl-Guard®, 180 Capsules has been analyzed for ingredient safety across all its components. Always consult your healthcare provider before starting any new supplement, especially if you take medications or have underlying health conditions.

Is Thorne a trustworthy supplement brand?

Thorne receives a brand trust score of 90/100 based on GoodSupp's independent analysis of certifications, regulatory history, and transparency practices. Founded in 1984 and headquartered in New York, NY, United States, the company offers 161 products in their lineup. They hold 4 verified certifications including Consumerlab, Nsf Certified For Sport, Nsf Gmp, Fda Gmp Inspections. Third-party certifications are independently verified and indicate the brand meets specific quality, purity, and manufacturing standards. Note: Thorne has 2 historical regulatory incidents on record, which are factored into the trust score.

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Disclaimer: GoodSupp provides independent supplement quality analysis for informational purposes only. Scores are generated algorithmically based on ingredient profiles, brand certifications, and public records. This is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Product data is sourced from manufacturer labels and public databases. GoodSupp is not affiliated with any supplement brand.