Natural Factors SAMe, 200 mg, 60 Slow Release Tablets supplement bottle
Natural Factors

SAMe, 200 mg, 60 Slow Release Tablets

What We Researched
1 active ingredient analyzed · 5 inactive ingredients decoded · 5 brand certifications checked · 3 retailers compared · Last updated: Mar 2026
62
Product Score Fair
88
Brand Score Good

Product Analysis

Transparency Excellent

Supplement Facts

IngredientAmount% DV
SAMe (S-Adenosyl-L-Methionine)(from 400 mg of S-Adenosyl-L-Methionine Tosylate Disulfate) 200 mg **
Bioavailability Fair

Absorption Rating

  • SAMe (S-Adenosyl-L-Methionine)(from 400 mg of S-Adenosyl-L-Methionine Tosylate Disulfate) Fair
Other Ingredients Excellent

Fillers & Additives

  • Microcrystalline Cellulose
  • Stearic Acid
  • Coating (glycerol, sodium alginate, colloidal silica anhydrous, arginine, magnesium stearate [vegetable grade])
  • Magnesium Stearate (Vegetable Grade)
  • Colloidal silica anhydrous
Efficacy Very Poor

Dosage Analysis

  • SAMe (S-Adenosyl-L-Methionine)(from 400 mg of S-Adenosyl-L-Methionine Tosylate Disulfate) 200 mg Under-dosed

Supplement Facts

Ingredient Amount % Daily Value
SAMe (S-Adenosyl-L-Methionine)(from 400 mg of S-Adenosyl-L-Methionine Tosylate Disulfate) 200 mg **

Other Ingredients

Inactive ingredients used in manufacturing. All rated for safety.

Microcrystalline Cellulose Safe

Adds bulk to small-dose supplements to make tablets/capsules a manageable size.

Stearic Acid Safe

Helps ingredients flow smoothly through manufacturing equipment.

Coating (glycerol, sodium alginate, colloidal silica anhydrous, arginine, magnesium stearate [vegetable grade]) Unknown
Magnesium Stearate (Vegetable Grade) Generally_safe

It is used to prevent ingredients from sticking to manufacturing equipment.

Colloidal silica anhydrous Unknown

Price Comparison

Price History

Tracked across major retailers. Updated periodically.

$37$36$35$34$33 Mar 12 $35.00$34.97
iHerb
Vitacost

Prices shown at time of last check. Click a retailer to see current price. GoodSupp is not affiliated with any retailer.

Brand Trust Report
Natural Factors

Founded 1950 · Coquitlam, British Columbia, Canada · 390 products · naturalfactors.com

Certifications

5 certifications
B Corp Certified Verified Source
Usp Verified Verified Source
Fda Gmp Inspections Verified Source
Non Gmo Project Verified Source
Usda Organic Verified Source

Transparency

4 claims
Third Party Testing Claim — Verified Source
Testing Lab Disclosure — Verified Source
In House Testing — Verified Source

Violation History

5 incidents
Prop 65 Lead2025-10-31Source
Recall Hi Potency B Complex, RevitalX, Super Multi® IRON FREE2024-07-19Source
Lawsuit Products labeled as containing glucosamine sulfate did not contain the ingredient.2021Source
Prop 65 Lead2016-01-13Source
Recall Natural Factors L-Arginine 500mg2006-04-05Source
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Frequently Asked Questions
Is Natural Factors SAMe, 200 mg a good supplement?

Natural Factors SAMe, 200 mg, 60 Slow Release Tablets received a product quality score of 62/100 in GoodSupp's independent analysis, suggesting some areas that could be improved. The product contains 1 active ingredients Of the 5 inactive ingredients, 2 are rated safe and 0 are flagged for review. The manufacturer, Natural Factors, holds a brand trust score of 88/100 with 5 verified certifications including B Corp Certified, Usp Verified, Fda Gmp Inspections, Non Gmo Project.

What are the ingredients in Natural Factors SAMe, 200 mg?

Natural Factors SAMe, 200 mg contains 1 active ingredients: SAMe (S-Adenosyl-L-Methionine)(from 400 mg of S-Adenosyl-L-Methionine Tosylate Disulfate) (200 mg). Each ingredient's dosage, form, and safety rating is analyzed independently in GoodSupp's full product breakdown.

Is Natural Factors SAMe, 200 mg safe to take?

Natural Factors SAMe, 200 mg, 60 Slow Release Tablets has been analyzed for ingredient safety across all its components. Always consult your healthcare provider before starting any new supplement, especially if you take medications or have underlying health conditions.

Is Natural Factors a trustworthy supplement brand?

Natural Factors receives a brand trust score of 88/100 based on GoodSupp's independent analysis of certifications, regulatory history, and transparency practices. Founded in 1950 and headquartered in Coquitlam, British Columbia, Canada, the company offers 390 products in their lineup. They hold 5 verified certifications including B Corp Certified, Usp Verified, Fda Gmp Inspections, Non Gmo Project. Third-party certifications are independently verified and indicate the brand meets specific quality, purity, and manufacturing standards. Note: Natural Factors has 5 historical regulatory incidents on record, which are factored into the trust score.

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Disclaimer: GoodSupp provides independent supplement quality analysis for informational purposes only. Scores are generated algorithmically based on ingredient profiles, brand certifications, and public records. This is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Product data is sourced from manufacturer labels and public databases. GoodSupp is not affiliated with any supplement brand.