Metagenics UltraGI Replenish®, Vanilla, 46.03 oz (1,305 g) supplement bottle
Metagenics

UltraGI Replenish®, Vanilla, 46.03 oz (1,305 g)

What We Researched
62 active ingredients analyzed · 16 inactive ingredients decoded · 7 brand certifications checked · 1 retailer compared · Last updated: Mar 2026
79
Product Score Fair
93
Brand Score Excellent

Product Analysis

Transparency Excellent

Supplement Facts

IngredientAmount% DV
Amino Acid mg/Serving
L-Alanine 740
L-Arginine*** 1,080
L-Aspartic Acid 1,360
L-Cysteine (Cysteine)*** 150
L-Glutamic Acid 2,050
L-Glutamine*** 310
Glycine*** 500
L-Histidine** 300
L-Isoleucine (BCAA)** 1,070
L-Leucine (BCAA)** 1,820
L-Lysine** (as L-lysine HCl) 1,650
L-Methionine** 160
L-Phenylalanine** 670
L-Proline*** 550
L-Serine*** 640
L-Threonine** 470
L-Tryptophan** 130
L-Tyrosine*** 490
L-Valine (BCAA)** 1,190
Each Serving Contains: %RDI
Vitamin D3 (as cholecalciferol) (400 IU) 10 mcg 50%
Calcium 40 mg 6%
Iron 3 mg 15%
Potassium 80 mg 0%
Vitamin A  (as retinyl palmitate) 370 mcg 40%
Vitamin C 30 mg 35%
Vitamin E 5 mg 35%
Thiamin 0.37 mg 30%
Riboflavin 0.42 mg 30%
Niacin 6.8 mg 40%
Vitamin B6 0.5 mg 30%
Folate (as calcium L-5-methyltetrahydrofolate) 310 mcg DFE 80%
Vitamin B12 (as methylcobalamin) 1.5 mcg 60%
Biotin 75 mcg 250%
Pantothenic Acid 2.5 mg 50%
Phosphorus 180 mg 15%
Iodine 37 mcg 25%
Magnesium 27 mg 8%
Zinc 11.2 mg 100%
Selenium 52 mcg 90%
Copper 1.5 mg 170%
Manganese 1.5 mg 70%
Chromium 120 mcg 340%
Chloride 260 mg 10%
Alpha-Linoleic Acid (ALA) (from flaxseed) 400 mg
L-Alanyl-L-Glutamine 500 mg
Isomalto-Oligosaccharide 5 g
2'-Fucosyllactose (2'-FL) 2 g
Bioavailability Excellent

Absorption Rating

  • Amino Acid Good
  • L-Alanine Good
  • L-Arginine*** Good
  • L-Aspartic Acid Good
  • L-Cysteine (Cysteine)*** Good
  • L-Glutamic Acid Fair
  • L-Glutamine*** Good
  • Glycine*** Good
  • L-Histidine** Good
  • L-Isoleucine (BCAA)** Good
  • L-Leucine (BCAA)** Good
  • L-Lysine** (as L-lysine HCl) Good
  • L-Methionine** Good
  • L-Phenylalanine** Good
  • L-Proline*** Good
  • L-Serine*** Good
  • L-Threonine** Good
  • L-Tryptophan** Good
  • L-Tyrosine*** Good
  • L-Valine (BCAA)** Good
  • Each Serving Contains: Fair
  • Vitamin D3 (as cholecalciferol) (400 IU) Good
  • Calcium Good
  • Iron Fair
  • Potassium Good
  • Vitamin A  (as retinyl palmitate) Good
  • Vitamin C Fair
  • Vitamin E Good
  • Thiamin Good
  • Riboflavin Good
  • Niacin Good
  • Vitamin B6 Fair
  • Folate (as calcium L-5-methyltetrahydrofolate) Good
  • Vitamin B12 (as methylcobalamin) Good
  • Biotin Good
  • Pantothenic Acid Good
  • Phosphorus Good
  • Iodine Good
  • Magnesium Good
  • Zinc Fair
  • Selenium Good
  • Copper Fair
  • Manganese Good
  • Chromium Fair
  • Chloride Good
  • Alpha-Linoleic Acid (ALA) (from flaxseed) Good
  • L-Alanyl-L-Glutamine Good
  • Isomalto-Oligosaccharide Fair
  • 2'-Fucosyllactose (2'-FL) Good
Other Ingredients Excellent

Fillers & Additives

  • Pea Protein Isolate
  • Bamboo fiber
  • Isomalto-oligosaccharide
  • Rice Protein Concentrate
  • Natural Flavor
  • ^ 2'-fucosyllactose powder
  • Fare olive oil
  • Gum Acacia
  • L-Lysine HCl
  • L-Leucine
  • Medium-Chain Triglycerides
  • L-Valine
  • Silicon Dioxide
  • L-alanyl-L-glutamine
  • L-Isoleucine
  • Luo Han Guo fruit (monk fruit) extract.^
Efficacy Poor

Dosage Analysis

  • L-Arginine*** 1,080 Under-dosed
  • L-Aspartic Acid 1,360 Under-dosed
  • L-Cysteine (Cysteine)*** 150 Under-dosed
  • L-Glutamic Acid 2,050 Effective
  • L-Glutamine*** 310 Under-dosed
  • Glycine*** 500 Under-dosed
  • L-Histidine** 300 Under-dosed
  • L-Isoleucine (BCAA)** 1,070 High
  • L-Leucine (BCAA)** 1,820 Under-dosed
  • L-Lysine** (as L-lysine HCl) 1,650 Effective
  • L-Methionine** 160 Under-dosed
  • L-Phenylalanine** 670 Effective
  • L-Proline*** 550 Effective
  • L-Serine*** 640 Effective
  • L-Tryptophan** 130 Under-dosed
  • L-Tyrosine*** 490 Under-dosed
  • L-Valine (BCAA)** 1,190 Effective
  • Vitamin D3 (as cholecalciferol) (400 IU) 10 mcg Under-dosed
  • Calcium 40 mg Under-dosed
  • Iron 3 mg Under-dosed
  • Potassium 80 mg Under-dosed
  • Vitamin A  (as retinyl palmitate) 370 mcg Under-dosed
  • Vitamin C 30 mg Under-dosed
  • Vitamin E 5 mg Under-dosed
  • Thiamin 0.37 mg Under-dosed
  • Riboflavin 0.42 mg Under-dosed
  • Niacin 6.8 mg Under-dosed
  • Vitamin B6 0.5 mg Under-dosed
  • Folate (as calcium L-5-methyltetrahydrofolate) 310 mcg DFE Under-dosed
  • Vitamin B12 (as methylcobalamin) 1.5 mcg Under-dosed
  • Biotin 75 mcg Effective
  • Pantothenic Acid 2.5 mg Under-dosed
  • Phosphorus 180 mg Under-dosed
  • Iodine 37 mcg Under-dosed
  • Magnesium 27 mg Under-dosed
  • Zinc 11.2 mg Effective
  • Selenium 52 mcg Effective
  • Copper 1.5 mg Effective
  • Manganese 1.5 mg Under-dosed
  • Chromium 120 mcg Effective
  • Chloride 260 mg Under-dosed
  • L-Alanyl-L-Glutamine 500 mg Under-dosed
  • Isomalto-Oligosaccharide 5 g Under-dosed
  • 2'-Fucosyllactose (2'-FL) 2 g Effective

Supplement Facts

Ingredient Amount % Daily Value
Calories 130
Total Fat 5 g
Saturated Fat† 1.5 g
Trans Fat 0 g
Polyunsaturated Fat 1 g
Monounsaturated Fat 2 g
Cholesterol 0 mg
Sodium 150 mg
Total Carbohydrate 16 g
Dietary Fiber 9 g
Total Sugars 3 g
Includes 2 g Added Sugars
Protein 12 g††
Amino Acid mg/Serving
L-Alanine 740
L-Arginine*** 1,080
L-Aspartic Acid 1,360
L-Cysteine (Cysteine)*** 150
L-Glutamic Acid 2,050
L-Glutamine*** 310
Glycine*** 500
L-Histidine** 300
L-Isoleucine (BCAA)** 1,070
L-Leucine (BCAA)** 1,820
L-Lysine** (as L-lysine HCl) 1,650
L-Methionine** 160
L-Phenylalanine** 670
L-Proline*** 550
L-Serine*** 640
L-Threonine** 470
L-Tryptophan** 130
L-Tyrosine*** 490
L-Valine (BCAA)** 1,190
Each Serving Contains: %RDI
Vitamin D3 (as cholecalciferol) (400 IU) 10 mcg 50%
Calcium 40 mg 6%
Iron 3 mg 15%
Potassium 80 mg 0%
Vitamin A  (as retinyl palmitate) 370 mcg 40%
Vitamin C 30 mg 35%
Vitamin E 5 mg 35%
Thiamin 0.37 mg 30%
Riboflavin 0.42 mg 30%
Niacin 6.8 mg 40%
Vitamin B6 0.5 mg 30%
Folate (as calcium L-5-methyltetrahydrofolate) 310 mcg DFE 80%
Vitamin B12 (as methylcobalamin) 1.5 mcg 60%
Biotin 75 mcg 250%
Pantothenic Acid 2.5 mg 50%
Phosphorus 180 mg 15%
Iodine 37 mcg 25%
Magnesium 27 mg 8%
Zinc 11.2 mg 100%
Selenium 52 mcg 90%
Copper 1.5 mg 170%
Manganese 1.5 mg 70%
Chromium 120 mcg 340%
Chloride 260 mg 10%
Alpha-Linoleic Acid (ALA) (from flaxseed) 400 mg
L-Alanyl-L-Glutamine 500 mg
Isomalto-Oligosaccharide 5 g
2'-Fucosyllactose (2'-FL) 2 g

Other Ingredients

Inactive ingredients used in manufacturing. All rated for safety.

Pea Protein Isolate Safe

It is used as a protein source and filler.

Bamboo fiber Unknown
Isomalto-oligosaccharide Generally_safe

It is used to add sweetness and provide prebiotic benefits.

Rice Protein Concentrate Generally_safe

It is used as a filler or protein source.

Natural Flavor Safe

Improves taste of chewable, gummy, or liquid supplements.

^ 2'-fucosyllactose powder Unknown
Fare olive oil Unknown
Gum Acacia Safe

It is used as a thickener, binder, or emulsifier.

L-Lysine HCl Safe

It is used as a source of L-lysine in supplements.

L-Leucine Safe

It is included for its potential muscle-building and recovery benefits.

Medium-Chain Triglycerides Generally_safe
L-Valine Generally_safe

It is included for its nutritional value.

Silicon Dioxide Safe

Prevents clumping and ensures consistent dosing.

L-alanyl-L-glutamine Unknown
L-Isoleucine Safe

It is included as an active ingredient for muscle support.

Luo Han Guo fruit (monk fruit) extract.^ Unknown

Price Comparison

Price History

Tracked across major retailers. Updated periodically.

$127$126$125$124$123 Mar 12 $125.00
iHerb

Prices shown at time of last check. Click a retailer to see current price. GoodSupp is not affiliated with any retailer.

Brand Trust Report
Metagenics

Founded 1983 · Aliso Viejo, California, United States · 185 products · metagenics.com

Certifications

7 certifications
B Corp Certified Verified Source
Consumerlab Verified
Gluten Free Gfco Verified Source
Non Gmo Project Verified Source
Fda Gmp Inspections Verified Source
Nsf Gmp Verified Source
Usp Verified Verified Source

Transparency

4 claims
Third Party Testing Claim — Verified Source
Coa Availability — Claimed Source
In House Testing — Verified Source

Violation History

3 incidents
Fda Warning A structure/function claim for 'Metagenics HerWellness Naturally Balanced' was deemed by the FDA to suggest the product is intended for use as a drug.2025-02-07Source
Prop 65 Lead2019-05-30Source
Fda Warning Mislabeling of 14 products as medical foods and making unapproved new drug claims.2013-08-13Source
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Frequently Asked Questions
Is Metagenics UltraGI Replenish®, Vanilla a good supplement?

Metagenics UltraGI Replenish®, Vanilla, 46.03 oz (1,305 g) received a product quality score of 79/100 in GoodSupp's independent analysis, suggesting some areas that could be improved. The product contains 62 active ingredients with 30 servings per container. Of the 16 inactive ingredients, 7 are rated safe and 0 are flagged for review. The manufacturer, Metagenics, holds a brand trust score of 93/100 with 7 verified certifications including B Corp Certified, Consumerlab, Gluten Free Gfco, Non Gmo Project.

What are the ingredients in Metagenics UltraGI Replenish®, Vanilla?

Metagenics UltraGI Replenish®, Vanilla contains 62 active ingredients: Calories (130), Total Fat (5 g), Saturated Fat† (1.5 g), Trans Fat (0 g), Polyunsaturated Fat (1 g), Monounsaturated Fat (2 g), and 56 more. Notable high-dose ingredients include Biotin at 250% DV, Chromium at 340% DV. Each ingredient's dosage, form, and safety rating is analyzed independently in GoodSupp's full product breakdown.

Is Metagenics UltraGI Replenish®, Vanilla safe to take?

Metagenics UltraGI Replenish®, Vanilla, 46.03 oz (1,305 g) has been analyzed for ingredient safety across all its components. Always consult your healthcare provider before starting any new supplement, especially if you take medications or have underlying health conditions.

Is Metagenics a trustworthy supplement brand?

Metagenics receives a brand trust score of 93/100 based on GoodSupp's independent analysis of certifications, regulatory history, and transparency practices. Founded in 1983 and headquartered in Aliso Viejo, California, United States, the company offers 185 products in their lineup. They hold 7 verified certifications including B Corp Certified, Consumerlab, Gluten Free Gfco, Non Gmo Project. Third-party certifications are independently verified and indicate the brand meets specific quality, purity, and manufacturing standards. Note: Metagenics has 3 historical regulatory incidents on record, which are factored into the trust score.

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Disclaimer: GoodSupp provides independent supplement quality analysis for informational purposes only. Scores are generated algorithmically based on ingredient profiles, brand certifications, and public records. This is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Product data is sourced from manufacturer labels and public databases. GoodSupp is not affiliated with any supplement brand.