Metagenics GI Sustain™, 24.2 oz (686 g) supplement bottle
Metagenics

GI Sustain™, 24.2 oz (686 g)

What We Researched
37 active ingredients analyzed · 9 inactive ingredients decoded · 7 brand certifications checked · 2 retailers compared · Last updated: Mar 2026
78
Product Score Fair
93
Brand Score Excellent

Product Analysis

Transparency Excellent

Supplement Facts

IngredientAmount% DV
Vitamin A (62.5% as beta-carotene) (as beta-carotene and retinyl palmitate) 1,200 mcg 133%
Vitamin C (as ascorbic acid) 102 mg 113%
Vitamin D (as cholecalciferol) (50 IU) 1.2 mcg 6%
Vitamin E (as d-alpha tocopheryl acetate) 33.5 mg 223%
Thiamin (as thiamin HCl) 0.5 mg 42%
Riboflavin 0.6 mg 46%
Niacin (as niacinamide) 10 mg 63%
Vitamin B6 (as pyridoxine HCl) 0.7 mg 41%
Folate (as calcium L-5-methyltetrahydrofolate) 235 mcg DFE 59%
Vitamin B12 (as methylcobalamin) 2.1 mcg 88%
Biotin 105 mcg 350%
Pantothenic Acid (as calcium D-pantothenate) 100 mg 2,000%
Calcium (as calcium citrate and dicalcium phosphate) 300 mg 23%
Iron (as ferrous fumarate) 3.6 mg 20%
Phosphorus (as dipotassium phosphate and dicalcium phosphate) 180 mg 14%
Magnesium (as magnesium citrate) 120 mg 29%
Zinc (as zinc gluconate) 7.5 mg 68%
Copper (as copper gluconate) 0.5 mg 56%
Manganese 1.3 mg 57%
Chromium (as chromium picolinate) 75 mcg 214%
Potassium (as dipotassium phosphate) 300 mg 6%
Isomalto-oligosaccharides 3.4 g ***
L-Glutamine 500 mg ***
Glycine 100 mg ***
DL-Methionine 100 mg ***
L-Lysine (as L-lysine HCl) 35 mg ***
L-Threonine 34 mg ***
L-Cysteine (as L-cysteine HCl) 25 mg ***
Bioavailability Excellent

Absorption Rating

  • Vitamin A (62.5% as beta-carotene) (as beta-carotene and retinyl palmitate) Good
  • Vitamin C (as ascorbic acid) Fair
  • Vitamin D (as cholecalciferol) (50 IU) Good
  • Vitamin E (as d-alpha tocopheryl acetate) Good
  • Thiamin (as thiamin HCl) Fair
  • Riboflavin Good
  • Niacin (as niacinamide) Good
  • Vitamin B6 (as pyridoxine HCl) Fair
  • Folate (as calcium L-5-methyltetrahydrofolate) Good
  • Vitamin B12 (as methylcobalamin) Good
  • Biotin Good
  • Pantothenic Acid (as calcium D-pantothenate) Good
  • Calcium (as calcium citrate and dicalcium phosphate) Fair
  • Iron (as ferrous fumarate) Fair
  • Phosphorus (as dipotassium phosphate and dicalcium phosphate) Good
  • Magnesium (as magnesium citrate) Good
  • Zinc (as zinc gluconate) Good
  • Copper (as copper gluconate) Good
  • Manganese Good
  • Chromium (as chromium picolinate) Good
  • Potassium (as dipotassium phosphate) Good
  • Isomalto-oligosaccharides Good
  • L-Glutamine Good
  • Glycine Good
  • DL-Methionine Good
  • L-Lysine (as L-lysine HCl) Good
  • L-Threonine Good
  • L-Cysteine (as L-cysteine HCl) Good
Other Ingredients Excellent

Fillers & Additives

  • Rice Protein Concentrate
  • Rice syrup solids
  • Apple Fiber
  • Olive Oil
  • Medium-Chain Triglycerides
  • Gum Acacia
  • Silica
  • Natural Flavors
  • Rice Maltodextrin
Efficacy Poor

Dosage Analysis

  • Vitamin A (62.5% as beta-carotene) (as beta-carotene and retinyl palmitate) 1,200 mcg Effective
  • Vitamin C (as ascorbic acid) 102 mg Effective
  • Vitamin D (as cholecalciferol) (50 IU) 1.2 mcg Under-dosed
  • Vitamin E (as d-alpha tocopheryl acetate) 33.5 mg Effective
  • Thiamin (as thiamin HCl) 0.5 mg Under-dosed
  • Riboflavin 0.6 mg Under-dosed
  • Niacin (as niacinamide) 10 mg Under-dosed
  • Vitamin B6 (as pyridoxine HCl) 0.7 mg Under-dosed
  • Folate (as calcium L-5-methyltetrahydrofolate) 235 mcg DFE Under-dosed
  • Vitamin B12 (as methylcobalamin) 2.1 mcg Under-dosed
  • Biotin 105 mcg Effective
  • Pantothenic Acid (as calcium D-pantothenate) 100 mg Effective
  • Calcium (as calcium citrate and dicalcium phosphate) 300 mg Under-dosed
  • Iron (as ferrous fumarate) 3.6 mg Under-dosed
  • Phosphorus (as dipotassium phosphate and dicalcium phosphate) 180 mg Under-dosed
  • Magnesium (as magnesium citrate) 120 mg Under-dosed
  • Zinc (as zinc gluconate) 7.5 mg Under-dosed
  • Copper (as copper gluconate) 0.5 mg Effective
  • Manganese 1.3 mg Under-dosed
  • Chromium (as chromium picolinate) 75 mcg Effective
  • Potassium (as dipotassium phosphate) 300 mg Under-dosed
  • Isomalto-oligosaccharides 3.4 g Under-dosed
  • L-Glutamine 500 mg Under-dosed
  • Glycine 100 mg Under-dosed
  • DL-Methionine 100 mg Under-dosed
  • L-Lysine (as L-lysine HCl) 35 mg Under-dosed
  • L-Cysteine (as L-cysteine HCl) 25 mg Under-dosed

Supplement Facts

Ingredient Amount % Daily Value
Calories 170
Total Fat 5 g 6%**
Saturated Fat 1.5 g 8%**
Total Carbohydrate 24 g 13%**
Dietary Fiber 5 g 7%**
Total Sugars 9 g ***
Includes 5g Added Sugars 10%**
Protein 13 g 26%**
Vitamin A (62.5% as beta-carotene) (as beta-carotene and retinyl palmitate) 1,200 mcg 133%
Vitamin C (as ascorbic acid) 102 mg 113%
Vitamin D (as cholecalciferol) (50 IU) 1.2 mcg 6%
Vitamin E (as d-alpha tocopheryl acetate) 33.5 mg 223%
Thiamin (as thiamin HCl) 0.5 mg 42%
Riboflavin 0.6 mg 46%
Niacin (as niacinamide) 10 mg 63%
Vitamin B6 (as pyridoxine HCl) 0.7 mg 41%
Folate (as calcium L-5-methyltetrahydrofolate) 235 mcg DFE 59%
Vitamin B12 (as methylcobalamin) 2.1 mcg 88%
Biotin 105 mcg 350%
Pantothenic Acid (as calcium D-pantothenate) 100 mg 2,000%
Calcium (as calcium citrate and dicalcium phosphate) 300 mg 23%
Iron (as ferrous fumarate) 3.6 mg 20%
Phosphorus (as dipotassium phosphate and dicalcium phosphate) 180 mg 14%
Magnesium (as magnesium citrate) 120 mg 29%
Zinc (as zinc gluconate) 7.5 mg 68%
Copper (as copper gluconate) 0.5 mg 56%
Manganese 1.3 mg 57%
Chromium (as chromium picolinate) 75 mcg 214%
Sodium 20 mg <1%
Potassium (as dipotassium phosphate) 300 mg 6%
Isomalto-oligosaccharides 3.4 g ***
L-Glutamine 500 mg ***
Glycine 100 mg ***
DL-Methionine 100 mg ***
L-Lysine (as L-lysine HCl) 35 mg ***
L-Threonine 34 mg ***
L-Cysteine (as L-cysteine HCl) 25 mg ***

Other Ingredients

Inactive ingredients used in manufacturing. All rated for safety.

Rice Protein Concentrate Generally_safe

It is used as a filler or protein source.

Rice syrup solids Unknown
Apple Fiber Safe

It is used to add bulk and improve the texture of supplements.

Olive Oil Safe

Helps dissolve and absorb fat-soluble vitamins (A, D, E, K).

Medium-Chain Triglycerides Generally_safe
Gum Acacia Safe

It is used as a thickener, binder, or emulsifier.

Silica Safe

Prevents ingredients from clumping and improves powder flow.

Natural Flavors Safe

Improves taste of chewable, gummy, or liquid supplements.

Rice Maltodextrin Generally_safe

It is used as a filler or binder.

Price Comparison

Price History

Tracked across major retailers. Updated periodically.

$97$96$95$94$93 Mar 12 $95.00
iHerb

Prices shown at time of last check. Click a retailer to see current price. GoodSupp is not affiliated with any retailer.

Brand Trust Report
Metagenics

Founded 1983 · Aliso Viejo, California, United States · 185 products · metagenics.com

Certifications

7 certifications
B Corp Certified Verified Source
Consumerlab Verified
Gluten Free Gfco Verified Source
Non Gmo Project Verified Source
Fda Gmp Inspections Verified Source
Nsf Gmp Verified Source
Usp Verified Verified Source

Transparency

4 claims
Third Party Testing Claim — Verified Source
Coa Availability — Claimed Source
In House Testing — Verified Source

Violation History

3 incidents
Fda Warning A structure/function claim for 'Metagenics HerWellness Naturally Balanced' was deemed by the FDA to suggest the product is intended for use as a drug.2025-02-07Source
Prop 65 Lead2019-05-30Source
Fda Warning Mislabeling of 14 products as medical foods and making unapproved new drug claims.2013-08-13Source
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Frequently Asked Questions
Is Metagenics GI Sustain™, 24.2 oz (686 g) a good supplement?

Metagenics GI Sustain™, 24.2 oz (686 g) received a product quality score of 78/100 in GoodSupp's independent analysis, suggesting some areas that could be improved. The product contains 37 active ingredients with 14 servings per container. Of the 9 inactive ingredients, 5 are rated safe and 0 are flagged for review. The manufacturer, Metagenics, holds a brand trust score of 93/100 with 7 verified certifications including B Corp Certified, Consumerlab, Gluten Free Gfco, Non Gmo Project.

What are the ingredients in Metagenics GI Sustain™, 24.2 oz (686 g)?

Metagenics GI Sustain™, 24.2 oz (686 g) contains 37 active ingredients: Calories (170), Total Fat (5 g), Saturated Fat (1.5 g), Total Carbohydrate (24 g), Dietary Fiber (5 g), Total Sugars (9 g), and 31 more. Notable high-dose ingredients include Vitamin E at 223% DV, Biotin at 350% DV, Pantothenic Acid at 2,000% DV. Each ingredient's dosage, form, and safety rating is analyzed independently in GoodSupp's full product breakdown.

Is Metagenics GI Sustain™, 24.2 oz (686 g) safe to take?

Metagenics GI Sustain™, 24.2 oz (686 g) has been analyzed for ingredient safety across all its components. Always consult your healthcare provider before starting any new supplement, especially if you take medications or have underlying health conditions.

Is Metagenics a trustworthy supplement brand?

Metagenics receives a brand trust score of 93/100 based on GoodSupp's independent analysis of certifications, regulatory history, and transparency practices. Founded in 1983 and headquartered in Aliso Viejo, California, United States, the company offers 185 products in their lineup. They hold 7 verified certifications including B Corp Certified, Consumerlab, Gluten Free Gfco, Non Gmo Project. Third-party certifications are independently verified and indicate the brand meets specific quality, purity, and manufacturing standards. Note: Metagenics has 3 historical regulatory incidents on record, which are factored into the trust score.

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Disclaimer: GoodSupp provides independent supplement quality analysis for informational purposes only. Scores are generated algorithmically based on ingredient profiles, brand certifications, and public records. This is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Product data is sourced from manufacturer labels and public databases. GoodSupp is not affiliated with any supplement brand.