Doctor's Best SAM-e, 400 mg supplement bottle
Doctor's Best

SAM-e, 400 mg

What We Researched
1 active ingredient analyzed · 10 inactive ingredients decoded · 1 brand certification checked · 1 retailer compared · Last updated: Mar 2026
100
Product Score Excellent
61
Brand Score Fair

Product Analysis

Transparency Excellent

Supplement Facts

IngredientAmount% DV
SAM-e (S-Adenosyl Methionine Disulfate Tosylate) 400 mg —
Bioavailability Excellent

Absorption Rating

  • SAM-e (S-Adenosyl Methionine Disulfate Tosylate) Good
Other Ingredients Excellent

Fillers & Additives

  • Microcrystalline Cellulose
  • Magnesium Silicate
  • Stearic Acid (Vegetable Source)
  • Croscarmellose Sodium
  • Vegetable stearates (vegetable source)
  • Shellac (pharmaceutical glaze)
  • Magnesium Hydroxide
  • Calcium Chloride
  • Sodium Alginate
  • Silicon Dioxide
Efficacy Excellent

Dosage Analysis

  • SAM-e (S-Adenosyl Methionine Disulfate Tosylate) 400 mg Effective

Supplement Facts

Ingredient Amount % Daily Value
SAM-e (S-Adenosyl Methionine Disulfate Tosylate) 400 mg

Other Ingredients

Inactive ingredients used in manufacturing. All rated for safety.

Microcrystalline Cellulose Safe

Adds bulk to small-dose supplements to make tablets/capsules a manageable size.

Magnesium Silicate Generally_safe

It is used to improve powder flow and prevent clumping.

Stearic Acid (Vegetable Source) Generally_safe

It is used as a lubricant and release agent.

Croscarmellose Sodium Safe

Helps tablets break apart and dissolve quickly in the stomach.

Vegetable stearates (vegetable source) Unknown
Shellac (pharmaceutical glaze) Unknown
Magnesium Hydroxide Generally_safe

It is used to provide magnesium.

Calcium Chloride Generally_safe

It is used as a source of calcium or as a firming agent.

Sodium Alginate Safe

It is used as a thickening agent and stabilizer.

Silicon Dioxide Safe

Prevents clumping and ensures consistent dosing.

Price Comparison

Prices shown at time of last check. Click a retailer to see current price. GoodSupp is not affiliated with any retailer.

Brand Trust Report
Doctor's Best

Founded 1990 · Tustin, California, USA · 186 products · doctorsbest.com

Certifications

1 certification
Fda Gmp Inspections Verified Source

Transparency

2 claims
Third Party Testing Claim — Claimed Source

Violation History

1 incident
Recall Red Yeast Rice2014-06-26Source
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Frequently Asked Questions
Is Doctor's Best SAM-e, 400 mg a good supplement?

Doctor's Best SAM-e, 400 mg received a product quality score of 100/100 in GoodSupp's independent analysis, placing it in the top tier of supplements we've analyzed. The product contains 1 active ingredients with 60 servings per container. Of the 10 inactive ingredients, 4 are rated safe and 0 are flagged for review. The manufacturer, Doctor's Best, holds a brand trust score of 61/100 with 1 verified certifications including Fda Gmp Inspections.

What are the ingredients in Doctor's Best SAM-e, 400 mg?

Doctor's Best SAM-e, 400 mg contains 1 active ingredients: SAM-e (S-Adenosyl Methionine Disulfate Tosylate) (400 mg). Each ingredient's dosage, form, and safety rating is analyzed independently in GoodSupp's full product breakdown.

Is Doctor's Best SAM-e, 400 mg safe to take?

Doctor's Best SAM-e, 400 mg has been analyzed for ingredient safety across all its components. Always consult your healthcare provider before starting any new supplement, especially if you take medications or have underlying health conditions.

Is Doctor's Best a trustworthy supplement brand?

Doctor's Best receives a brand trust score of 61/100 based on GoodSupp's independent analysis of certifications, regulatory history, and transparency practices. Founded in 1990 and headquartered in Tustin, California, USA, the company offers 186 products in their lineup. They hold 1 verified certifications including Fda Gmp Inspections. Third-party certifications are independently verified and indicate the brand meets specific quality, purity, and manufacturing standards. Note: Doctor's Best has 1 historical regulatory incident on record, which are factored into the trust score.

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Disclaimer: GoodSupp provides independent supplement quality analysis for informational purposes only. Scores are generated algorithmically based on ingredient profiles, brand certifications, and public records. This is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Product data is sourced from manufacturer labels and public databases. GoodSupp is not affiliated with any supplement brand.