21st Century B-100 Complex, Prolonged Release, 60 Tablets supplement bottle
21st Century

B-100 Complex, Prolonged Release, 60 Tablets

What We Researched
9 active ingredients analyzed · 12 inactive ingredients decoded · 2 brand certifications checked · 2 retailers compared · Last updated: Mar 2026
84
Product Score Good
76
Brand Score Fair

Product Analysis

Transparency Excellent

Supplement Facts

IngredientAmount% DV
Thiamin (as Thiamin Mononitrate, Vitamin B-1) 100 mg 8,333%
Riboflavin (Vitamin B-2) 100 mg 7,692%
Niacin (as Niacinamide) 100 mg 625%
Vitamin B-6 (as Pyridoxine HCl) 100 mg 5,882%
Folate (400 mcg Folic Acid 667 mcg DFE 167%
Vitamin B-12 (as Cyanocobalamin) 100 mcg 4,167%
Biotin 100 mcg 333%
Pantothenic Acid (as d-Calcium Pantothenate) 100 mg 2,000%
Calcium (as Calcium Carbonate) 124 mg 10%
Bioavailability Good

Absorption Rating

  • Thiamin (as Thiamin Mononitrate, Vitamin B-1) Fair
  • Riboflavin (Vitamin B-2) Good
  • Niacin (as Niacinamide) Good
  • Vitamin B-6 (as Pyridoxine HCl) Fair
  • Folate (400 mcg Folic Acid Fair
  • Vitamin B-12 (as Cyanocobalamin) Fair
  • Biotin Good
  • Pantothenic Acid (as d-Calcium Pantothenate) Good
  • Calcium (as Calcium Carbonate) Fair
Other Ingredients Very Good

Fillers & Additives

  • Cellulose
  • Stearic Acid
  • Hydroxypropyl Methylcellulose
  • Silicon Dioxide
  • Dicalcium Phosphate
  • Ethylcellulose
  • Magnesium Silicate
  • Magnesium Stearate
  • Pharmaceutical Glaze
  • Polyethylene Glycol Low
  • Polysorbate Medium
  • Polyvinyl Alcohol
Efficacy Very Good

Dosage Analysis

  • Thiamin (as Thiamin Mononitrate, Vitamin B-1) 100 mg Effective
  • Riboflavin (Vitamin B-2) 100 mg Effective
  • Niacin (as Niacinamide) 100 mg High
  • Vitamin B-6 (as Pyridoxine HCl) 100 mg Effective
  • Folate (400 mcg Folic Acid 667 mcg DFE Effective
  • Vitamin B-12 (as Cyanocobalamin) 100 mcg Effective
  • Biotin 100 mcg Effective
  • Pantothenic Acid (as d-Calcium Pantothenate) 100 mg Effective
  • Calcium (as Calcium Carbonate) 124 mg Under-dosed

Supplement Facts

Ingredient Amount % Daily Value
Thiamin (as Thiamin Mononitrate, Vitamin B-1) 100 mg 8,333%
Riboflavin (Vitamin B-2) 100 mg 7,692%
Niacin (as Niacinamide) 100 mg 625%
Vitamin B-6 (as Pyridoxine HCl) 100 mg 5,882%
Folate (400 mcg Folic Acid 667 mcg DFE 167%
Vitamin B-12 (as Cyanocobalamin) 100 mcg 4,167%
Biotin 100 mcg 333%
Pantothenic Acid (as d-Calcium Pantothenate) 100 mg 2,000%
Calcium (as Calcium Carbonate) 124 mg 10%

Other Ingredients

Inactive ingredients used in manufacturing. All rated for safety.

Cellulose Safe

Provides bulk and structure in tablets and capsules.

Stearic Acid Safe

Helps ingredients flow smoothly through manufacturing equipment.

Hydroxypropyl Methylcellulose Safe

It is used as a coating for tablets and capsules.

Silicon Dioxide Safe

Prevents clumping and ensures consistent dosing.

Dicalcium Phosphate Safe

Serves as both a filler and a supplemental source of calcium and phosphorus.

Ethylcellulose Generally_safe

It is used as a coating to control the release of supplement ingredients.

Magnesium Silicate Generally_safe

It is used to improve powder flow and prevent clumping.

Magnesium Stearate Safe

Prevents ingredients from sticking to manufacturing equipment during tableting.

Pharmaceutical Glaze Generally_safe

It is used to coat tablets or capsules for easier swallowing or controlled release.

Polyethylene Glycol Caution

It is used as a binder, coating agent, or to improve solubility.

Polysorbate Generally_safe

It is used to help mix oil and water-based ingredients.

Polyvinyl Alcohol Generally_safe

It is used as a coating for tablets or capsules.

Price Comparison

Price History

Tracked across major retailers. Updated periodically.

$11$10$9$8$7 Mar 12 $9.49
iHerb

Prices shown at time of last check. Click a retailer to see current price. GoodSupp is not affiliated with any retailer.

Brand Trust Report
21st Century

Founded 1991 · Tempe, Arizona, United States · 231 products · 21stcenturyvitamins.com/

Certifications

2 certifications
Consumerlab Verified
Nsf Gmp Verified Source

Transparency

4 claims
Third Party Testing Claim — Claimed Source
Testing Lab Disclosure — Verified Source
In House Testing — Verified Source

Violation History

4 incidents
Prop 65 Lead2021-06-22Source
Recall Vitamin D3 5000 IU Tablets2021-05-19Source
Lawsuit False advertising of Glucosamine/Chondroitin supplements.2012Source
Prop 65 Lead2008-12-23Source
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Frequently Asked Questions
Is 21st Century B-100 Complex, Prolonged Release a good supplement?

21st Century B-100 Complex, Prolonged Release, 60 Tablets received a product quality score of 84/100 in GoodSupp's independent analysis, indicating strong overall quality. The product contains 9 active ingredients Of the 12 inactive ingredients, 6 are rated safe and 1 are flagged for review. The manufacturer, 21st Century, holds a brand trust score of 76/100 with 2 verified certifications including Consumerlab, Nsf Gmp.

What are the ingredients in 21st Century B-100 Complex, Prolonged Release?

21st Century B-100 Complex, Prolonged Release contains 9 active ingredients: Thiamin (as Thiamin Mononitrate, Vitamin B-1) (100 mg), Riboflavin (Vitamin B-2) (100 mg), Niacin (as Niacinamide) (100 mg), Vitamin B-6 (as Pyridoxine HCl) (100 mg), Folate (400 mcg Folic Acid (667 mcg DFE), Vitamin B-12 (as Cyanocobalamin) (100 mcg), and 3 more. Notable high-dose ingredients include Thiamin at 8,333% DV, Riboflavin at 7,692% DV, Niacin at 625% DV. Each ingredient's dosage, form, and safety rating is analyzed independently in GoodSupp's full product breakdown.

Is 21st Century B-100 Complex, Prolonged Release safe to take?

21st Century B-100 Complex, Prolonged Release, 60 Tablets has been analyzed for ingredient safety across all its components. Of 12 inactive ingredients, 6 are rated safe. 1 ingredient is flagged for review: Polyethylene Glycol. 'Caution' doesn't mean dangerous — it indicates the ingredient has some considerations worth being aware of, such as potential sensitivities or ongoing research. Always consult your healthcare provider before starting any new supplement, especially if you take medications or have underlying health conditions.

Is 21st Century a trustworthy supplement brand?

21st Century receives a brand trust score of 76/100 based on GoodSupp's independent analysis of certifications, regulatory history, and transparency practices. Founded in 1991 and headquartered in Tempe, Arizona, United States, the company offers 231 products in their lineup. They hold 2 verified certifications including Consumerlab, Nsf Gmp. Third-party certifications are independently verified and indicate the brand meets specific quality, purity, and manufacturing standards. Note: 21st Century has 4 historical regulatory incidents on record, which are factored into the trust score.

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Disclaimer: GoodSupp provides independent supplement quality analysis for informational purposes only. Scores are generated algorithmically based on ingredient profiles, brand certifications, and public records. This is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Product data is sourced from manufacturer labels and public databases. GoodSupp is not affiliated with any supplement brand.