21st Century Advanced Formula Hair, Skin & Nails, 50 Tablets supplement bottle
21st Century

Advanced Formula Hair, Skin & Nails, 50 Tablets

What We Researched
30 active ingredients analyzed · 12 inactive ingredients decoded · 2 brand certifications checked · 3 retailers compared · Last updated: Mar 2026
48
Product Score Poor
76
Brand Score Fair

Product Analysis

Transparency Excellent

Supplement Facts

IngredientAmount% DV
Vitamin A (as Palmitate) 750 mcg RAE 83%
Vitamin C (as Ascorbic Acid) 50 mg 56%
Vitamin D3 (as Cholecalciferol) (50 IU) 1.25 mcg 6%
Vitamin E (as dl-Alpha Tocopheryl Acetate) 11.25 mg 75%
Thiamin (Thiamin Mononitrate, B-1) 5 mg 417%
Riboflavin (Vitamin B-2) 5 mg 385%
Niacin 7.5 mg 47%
Vitamin B-6 (as Pyridoxine HCl) 6.5 mg 382%
Folate (25 mcg Folic Acid) 42 mcg DFE 10%
Vitamin B-12 (Cyanocobalamin) 25 mcg 1,042%
Biotin 25 mcg 83%
Pantothenic Acid (as d-Calcium Pantothenate) 15 mg 300%
Choline (as Choline Bitartrate) 25 mg 5%
Calcium (as Dicalcium Phosphate & Calcium Carbonate) 125 mg 10%
Iron (as Ferrous Fumarate) 3.3 mg 18%
Phosphorous (as Dicalcium Phosphate) 58 mg 5%
Iodine (as Potassium Iodide) 150 mcg 100%
Magnesium (as Magnesium Oxide) 20 mg 5%
Zinc (as Zinc Gluconate) 0.6 mg 5%
Manganese (as Manganese Sulfate) 0.6 mg 26%
Potassium (as Potassium Iodide & Potassium Sulfate) 5 mg <1%
Betaine HCl 10 mg **
Inositol 10 mg **
PABA 10 mg **
DNA 10 mg **
RNA 10 mg **
Tyrosine 7.2 mg **
Cysteine HCl 3.5 mg **
Soy Protein (Amino Acid Blend)Glutamic Acid, Lysine, Leucine, Aspartic Acid, Isoleucine, Valine, Alanine, Arginine, Histidine, Serine, Threonine, Glycine, Ornithine HCl 50 mg **
Proprietary Herbal Support BlendBrewers Yeast, Soy Protein, Horsetail Powder (Equisetum arvense) (aerial), Parsley Leaf, Rose Hips Powder (Rosa canina L.) (fruit), Watercress (Nasturtium officinale R.Br.) (whole herb), Kelp Powder (whole plant), Citrus Bioflavonoids, Lecithin, Rutin. 310 mg **
Bioavailability Good

Absorption Rating

  • Vitamin A (as Palmitate) Good
  • Vitamin C (as Ascorbic Acid) Fair
  • Vitamin D3 (as Cholecalciferol) (50 IU) Good
  • Vitamin E (as dl-Alpha Tocopheryl Acetate) Poor
  • Thiamin (Thiamin Mononitrate, B-1) Fair
  • Riboflavin (Vitamin B-2) Good
  • Niacin Good
  • Vitamin B-6 (as Pyridoxine HCl) Fair
  • Folate (25 mcg Folic Acid) Fair
  • Vitamin B-12 (Cyanocobalamin) Fair
  • Biotin Good
  • Pantothenic Acid (as d-Calcium Pantothenate) Good
  • Choline (as Choline Bitartrate) Poor
  • Calcium (as Dicalcium Phosphate & Calcium Carbonate) Fair
  • Iron (as Ferrous Fumarate) Fair
  • Phosphorous (as Dicalcium Phosphate) Fair
  • Iodine (as Potassium Iodide) Good
  • Magnesium (as Magnesium Oxide) Poor
  • Zinc (as Zinc Gluconate) Good
  • Manganese (as Manganese Sulfate) Good
  • Potassium (as Potassium Iodide & Potassium Sulfate) Good
  • Betaine HCl Fair
  • Inositol Good
  • PABA Good
  • DNA Fair
  • RNA Fair
  • Tyrosine Good
  • Cysteine HCl Fair
  • Soy Protein (Amino Acid Blend)Glutamic Acid, Lysine, Leucine, Aspartic Acid, Isoleucine, Valine, Alanine, Arginine, Histidine, Serine, Threonine, Glycine, Ornithine HCl Fair
  • Proprietary Herbal Support BlendBrewers Yeast, Soy Protein, Horsetail Powder (Equisetum arvense) (aerial), Parsley Leaf, Rose Hips Powder (Rosa canina L.) (fruit), Watercress (Nasturtium officinale R.Br.) (whole herb), Kelp Powder (whole plant), Citrus Bioflavonoids, Lecithin, Rutin. Fair
Other Ingredients Poor

Fillers & Additives

  • Cellulose
  • Stearic Acid
  • Maltodextrin
  • Croscarmellose Sodium
  • Artificial colors (fd&c blue #2 carmine, fd&c red #40) High
  • Gelatin
  • Magnesium Silicate
  • Magnesium Stearate
  • Polyethylene Glycol Low
  • Polyvinyl Alcohol
  • Silicon Dioxide
  • Titanium Dioxide High
Efficacy Poor

Dosage Analysis

  • Vitamin A (as Palmitate) 750 mcg RAE Effective
  • Vitamin C (as Ascorbic Acid) 50 mg Under-dosed
  • Vitamin D3 (as Cholecalciferol) (50 IU) 1.25 mcg Under-dosed
  • Vitamin E (as dl-Alpha Tocopheryl Acetate) 11.25 mg Under-dosed
  • Thiamin (Thiamin Mononitrate, B-1) 5 mg Effective
  • Riboflavin (Vitamin B-2) 5 mg Effective
  • Niacin 7.5 mg Under-dosed
  • Vitamin B-6 (as Pyridoxine HCl) 6.5 mg Effective
  • Folate (25 mcg Folic Acid) 42 mcg DFE Under-dosed
  • Vitamin B-12 (Cyanocobalamin) 25 mcg Effective
  • Biotin 25 mcg Under-dosed
  • Pantothenic Acid (as d-Calcium Pantothenate) 15 mg Effective
  • Choline (as Choline Bitartrate) 25 mg Under-dosed
  • Calcium (as Dicalcium Phosphate & Calcium Carbonate) 125 mg Under-dosed
  • Iron (as Ferrous Fumarate) 3.3 mg Under-dosed
  • Iodine (as Potassium Iodide) 150 mcg Effective
  • Magnesium (as Magnesium Oxide) 20 mg Under-dosed
  • Zinc (as Zinc Gluconate) 0.6 mg Under-dosed
  • Manganese (as Manganese Sulfate) 0.6 mg Under-dosed
  • Potassium (as Potassium Iodide & Potassium Sulfate) 5 mg Under-dosed
  • Betaine HCl 10 mg Under-dosed
  • Inositol 10 mg Under-dosed
  • PABA 10 mg Under-dosed
  • Tyrosine 7.2 mg Under-dosed
  • Cysteine HCl 3.5 mg Under-dosed
  • Soy Protein (Amino Acid Blend)Glutamic Acid, Lysine, Leucine, Aspartic Acid, Isoleucine, Valine, Alanine, Arginine, Histidine, Serine, Threonine, Glycine, Ornithine HCl 50 mg Under-dosed

Supplement Facts

Ingredient Amount % Daily Value
Vitamin A (as Palmitate) 750 mcg RAE 83%
Vitamin C (as Ascorbic Acid) 50 mg 56%
Vitamin D3 (as Cholecalciferol) (50 IU) 1.25 mcg 6%
Vitamin E (as dl-Alpha Tocopheryl Acetate) 11.25 mg 75%
Thiamin (Thiamin Mononitrate, B-1) 5 mg 417%
Riboflavin (Vitamin B-2) 5 mg 385%
Niacin 7.5 mg 47%
Vitamin B-6 (as Pyridoxine HCl) 6.5 mg 382%
Folate (25 mcg Folic Acid) 42 mcg DFE 10%
Vitamin B-12 (Cyanocobalamin) 25 mcg 1,042%
Biotin 25 mcg 83%
Pantothenic Acid (as d-Calcium Pantothenate) 15 mg 300%
Choline (as Choline Bitartrate) 25 mg 5%
Calcium (as Dicalcium Phosphate & Calcium Carbonate) 125 mg 10%
Iron (as Ferrous Fumarate) 3.3 mg 18%
Phosphorous (as Dicalcium Phosphate) 58 mg 5%
Iodine (as Potassium Iodide) 150 mcg 100%
Magnesium (as Magnesium Oxide) 20 mg 5%
Zinc (as Zinc Gluconate) 0.6 mg 5%
Manganese (as Manganese Sulfate) 0.6 mg 26%
Potassium (as Potassium Iodide & Potassium Sulfate) 5 mg <1%
Betaine HCl 10 mg **
Inositol 10 mg **
PABA 10 mg **
DNA 10 mg **
RNA 10 mg **
Tyrosine 7.2 mg **
Cysteine HCl 3.5 mg **
Soy Protein (Amino Acid Blend)Glutamic Acid, Lysine, Leucine, Aspartic Acid, Isoleucine, Valine, Alanine, Arginine, Histidine, Serine, Threonine, Glycine, Ornithine HCl 50 mg **
Proprietary Herbal Support BlendBrewers Yeast, Soy Protein, Horsetail Powder (Equisetum arvense) (aerial), Parsley Leaf, Rose Hips Powder (Rosa canina L.) (fruit), Watercress (Nasturtium officinale R.Br.) (whole herb), Kelp Powder (whole plant), Citrus Bioflavonoids, Lecithin, Rutin. 310 mg **

Other Ingredients

Inactive ingredients used in manufacturing. All rated for safety.

Cellulose Safe

Provides bulk and structure in tablets and capsules.

Stearic Acid Safe

Helps ingredients flow smoothly through manufacturing equipment.

Maltodextrin Generally_safe

Helps carry and stabilize active ingredients. Provides bulk.

Croscarmellose Sodium Safe

Helps tablets break apart and dissolve quickly in the stomach.

Artificial colors (fd&c blue #2 carmine, fd&c red #40) Unknown
Gelatin Safe

Forms the capsule shell that holds the supplement contents.

Magnesium Silicate Generally_safe

It is used to improve powder flow and prevent clumping.

Magnesium Stearate Safe

Prevents ingredients from sticking to manufacturing equipment during tableting.

Polyethylene Glycol Caution

It is used as a binder, coating agent, or to improve solubility.

Polyvinyl Alcohol Generally_safe

It is used as a coating for tablets or capsules.

Silicon Dioxide Safe

Prevents clumping and ensures consistent dosing.

Titanium Dioxide Caution

Used as a whitening agent in tablet coatings and capsules.

Price Comparison

Price History

Tracked across major retailers. Updated periodically.

$9$8$7$6$5 Mar 12 $7.00
iHerb

Prices shown at time of last check. Click a retailer to see current price. GoodSupp is not affiliated with any retailer.

Brand Trust Report
21st Century

Founded 1991 · Tempe, Arizona, United States · 231 products · 21stcenturyvitamins.com/

Certifications

2 certifications
Consumerlab Verified
Nsf Gmp Verified Source

Transparency

4 claims
Third Party Testing Claim — Claimed Source
Testing Lab Disclosure — Verified Source
In House Testing — Verified Source

Violation History

4 incidents
Prop 65 Lead2021-06-22Source
Recall Vitamin D3 5000 IU Tablets2021-05-19Source
Lawsuit False advertising of Glucosamine/Chondroitin supplements.2012Source
Prop 65 Lead2008-12-23Source
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Frequently Asked Questions
Is 21st Century Advanced Formula Hair, Skin & Nails a good supplement?

21st Century Advanced Formula Hair, Skin & Nails, 50 Tablets received a product quality score of 48/100 in GoodSupp's independent analysis, indicating several areas of concern that consumers should review. The product contains 30 active ingredients Of the 12 inactive ingredients, 6 are rated safe and 2 are flagged for review. The manufacturer, 21st Century, holds a brand trust score of 76/100 with 2 verified certifications including Consumerlab, Nsf Gmp.

What are the ingredients in 21st Century Advanced Formula Hair, Skin & Nails?

21st Century Advanced Formula Hair, Skin & Nails contains 30 active ingredients: Vitamin A (as Palmitate) (750 mcg RAE), Vitamin C (as Ascorbic Acid) (50 mg), Vitamin D3 (as Cholecalciferol) (50 IU) (1.25 mcg), Vitamin E (as dl-Alpha Tocopheryl Acetate) (11.25 mg), Thiamin (Thiamin Mononitrate, B-1) (5 mg), Riboflavin (Vitamin B-2) (5 mg), and 24 more. Notable high-dose ingredients include Thiamin at 417% DV, Riboflavin at 385% DV, Vitamin B-6 at 382% DV. Each ingredient's dosage, form, and safety rating is analyzed independently in GoodSupp's full product breakdown.

Is 21st Century Advanced Formula Hair, Skin & Nails safe to take?

21st Century Advanced Formula Hair, Skin & Nails, 50 Tablets has been analyzed for ingredient safety across all its components. Of 12 inactive ingredients, 6 are rated safe. 2 ingredients are flagged for review: Polyethylene Glycol, Titanium Dioxide. 'Caution' doesn't mean dangerous — it indicates the ingredient has some considerations worth being aware of, such as potential sensitivities or ongoing research. Always consult your healthcare provider before starting any new supplement, especially if you take medications or have underlying health conditions.

Is 21st Century a trustworthy supplement brand?

21st Century receives a brand trust score of 76/100 based on GoodSupp's independent analysis of certifications, regulatory history, and transparency practices. Founded in 1991 and headquartered in Tempe, Arizona, United States, the company offers 231 products in their lineup. They hold 2 verified certifications including Consumerlab, Nsf Gmp. Third-party certifications are independently verified and indicate the brand meets specific quality, purity, and manufacturing standards. Note: 21st Century has 4 historical regulatory incidents on record, which are factored into the trust score.

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Disclaimer: GoodSupp provides independent supplement quality analysis for informational purposes only. Scores are generated algorithmically based on ingredient profiles, brand certifications, and public records. This is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Product data is sourced from manufacturer labels and public databases. GoodSupp is not affiliated with any supplement brand.