Vitamin D3 (Cholecalciferol)

Generally Safe OtherSynthetic

Vitamin D3 (Cholecalciferol) is a synthetic other used in dietary supplements. Safety rating: Generally Safe. It is generally considered safe for most people at standard doses. Found in 20 supplements in the GoodSupp database. Vitamin D3 (cholecalciferol) is a fat-soluble vitamin.

20 Products use this
Generally Safe Safety rating
Other Category
No Natural origin

Safety Verdict: Generally Safe

Excessive intake can lead to hypervitaminosis D.

What is Vitamin D3 (Cholecalciferol)?

Vitamin D3 (cholecalciferol) is a fat-soluble vitamin.

Common Names Vitamin D3 (Cholecalciferol), Cholecalciferol
Type Other
Origin Synthetic / Manufactured
Safety Rating Generally Safe

Why is Vitamin D3 (Cholecalciferol) used in supplements?

It is added as a nutritional component.

Role in supplements: Other — serves a functional role in supplement formulation.

Should you be concerned about Vitamin D3 (Cholecalciferol)?

Generally no. Vitamin D3 (Cholecalciferol) is considered safe for most people at typical supplement doses. Some individuals may want to be aware of minor sensitivities.

Excessive intake can lead to hypervitaminosis D.

Low risk. Generally safe for most people in supplement amounts.

Top-rated products containing Vitamin D3 (Cholecalciferol)

These 20 highest-scoring supplements in our database use Vitamin D3 (Cholecalciferol).

Carlson Carlson - Vitamin D3, 1000 IU (25 mcg), Cholecalciferol, Vitamin D Supplements, Vitamin D3 Soft Gels, 250 Softgels
Carlson Carlson - Vitamin D3, 1000 IU (25 mcg), Cholecalciferol, Vitamin D Supplements, Vitamin D3 Soft Gels, 250 Softgels
Product 100 Brand N/A
Alora Naturals Alora Naturals Liquid Vitamin D3 | High Potency 1000 IU Vitamin D3 (choleclciferol) | Calcium Absorption, Immune Support, Strengthens Bones & Joints | Vegan, 50mL
Alora Naturals Alora Naturals Liquid Vitamin D3 | High Potency 1000 IU Vitamin D3 (choleclciferol) | Calcium Absorption, Immune Support, Strengthens Bones & Joints | Vegan, 50mL
Product 100 Brand N/A
Carlson Carlson - Vitamin D3, 2500 IU (62.5 mcg), Cholecalciferol, Vitamin D Supplements, Vitamin D3 Soft Gels, 150 Softgels
Carlson Carlson - Vitamin D3, 2500 IU (62.5 mcg), Cholecalciferol, Vitamin D Supplements, Vitamin D3 Soft Gels, 150 Softgels
Product 100 Brand N/A
Kroger Vitamin D 50mcg Bone Supplement Dietary Supplement
Kroger Vitamin D 50mcg Bone Supplement Dietary Supplement
Product 100 Brand N/A
Citracal Citracal
Citracal Citracal
Product 88 Brand N/A
Sanniti Cod Liver Oil, 1081 mg
Sanniti Cod Liver Oil, 1081 mg
Product 88 Brand N/A
Jointace Vitabiotics Jointace Glucosamine and Chondroitin 90 Tablets
Jointace Vitabiotics Jointace Glucosamine and Chondroitin 90 Tablets
Product 85 Brand N/A
Nature Made Calcium with Vitamin D3, 600 mg, 120 Tablets
Nature Made Calcium with Vitamin D3, 600 mg, 120 Tablets
Product 82 Brand N/A
One-A-Day Prenatal 1 with Folic Acid, DHA & Iron, Multivitamin/Multimineral Supplement, 30 Softgels
One-A-Day Prenatal 1 with Folic Acid, DHA & Iron, Multivitamin/Multimineral Supplement, 30 Softgels
Product 81 Brand N/A
One-A-Day Prenatal Advanced, Complete Multivitamin with Brain Support, 60 Prenatal Multivitamin Softgels & 60 Prenatal Choline Tablets
One-A-Day Prenatal Advanced, Complete Multivitamin with Brain Support, 60 Prenatal Multivitamin Softgels & 60 Prenatal Choline Tablets
Product 81 Brand N/A
Designer Wellness Designer Lite, Plant + Whey Protein Powder, Chocolate Cookies & Cream, 9.03 oz (256 g)
Designer Wellness Designer Lite, Plant + Whey Protein Powder, Chocolate Cookies & Cream, 9.03 oz (256 g)
Product 81 Brand N/A
Designer Wellness Designer Lite®, Plant + Whey Protein Powder, Vanilla Cupcake, 1.6 lb (720 g)
Designer Wellness Designer Lite®, Plant + Whey Protein Powder, Vanilla Cupcake, 1.6 lb (720 g)
Product 81 Brand N/A
Designer Wellness Designer Lite®, Plant + Whey Protein Powder, Chocolate Cookies & Cream, 1.6 lb (720 g)
Designer Wellness Designer Lite®, Plant + Whey Protein Powder, Chocolate Cookies & Cream, 1.6 lb (720 g)
Product 81 Brand N/A
Igennus Pure & Essential Omega-3 Wild Fish Oil + Vitamin D3 – Ultra Pure rTG 1-a-Day Natural Lemon, 60 Softgels
Igennus Pure & Essential Omega-3 Wild Fish Oil + Vitamin D3 – Ultra Pure rTG 1-a-Day Natural Lemon, 60 Softgels
Product 80 Brand N/A
Revive Collagen Hydrolyzed Marine Collagen, 10000 mg, Tropical Flavor
Revive Collagen Hydrolyzed Marine Collagen, 10000 mg, Tropical Flavor
Product 80 Brand N/A
One-A-Day VitaCraves®, Women's Multivitamin/Multimineral Supplement Gummies, 170 Gummies
One-A-Day VitaCraves®, Women's Multivitamin/Multimineral Supplement Gummies, 170 Gummies
Product 79 Brand N/A
Perk Chill Drink Mix (Mexican Hot Chocolate) 10 Stick Packs
Perk Chill Drink Mix (Mexican Hot Chocolate) 10 Stick Packs
Product 79 Brand N/A
Perk Chill Drink Mix (Chocolate Salted Caramel Pretzel) 10 Stick Packs
Perk Chill Drink Mix (Chocolate Salted Caramel Pretzel) 10 Stick Packs
Product 79 Brand N/A
Flintstones Children's Multivitamin, + Immunity Support, 150 Gummies
Flintstones Children's Multivitamin, + Immunity Support, 150 Gummies
Product 78 Brand N/A
Perk Energy Berries and Cream, 13.55 oz (384 g)
Perk Energy Berries and Cream, 13.55 oz (384 g)
Product 76 Brand N/A
Related Ingredients
Frequently Asked Questions
Is Vitamin D3 (Cholecalciferol) safe in supplements?

Vitamin D3 (Cholecalciferol) is rated generally safe for most people at amounts commonly found in supplements. While the overall safety profile is favorable, some individuals may experience minor sensitivities. Excessive intake can lead to hypervitaminosis D. In GoodSupp's database, 20 products contain this ingredient. Consult your healthcare provider if you have specific concerns.

What is Vitamin D3 (Cholecalciferol) and why is it in my supplement?

Vitamin D3 (cholecalciferol) is a fat-soluble vitamin. It appears in 20 products in the GoodSupp database.

Is Vitamin D3 (Cholecalciferol) natural or synthetic?

Vitamin D3 (Cholecalciferol) is synthetically produced, meaning it is manufactured through chemical processes rather than directly extracted from natural sources. Synthetic ingredients are extremely common in supplements and are not inherently less safe than natural alternatives. In many cases, synthetic production allows for higher purity and more consistent quality. The FDA regulates both natural and synthetic supplement ingredients under the same safety standards. GoodSupp rates ingredients based on their actual safety data regardless of whether they're natural or synthetic.

Is cholecalciferol synthetic?

This is an important question for supplement consumers. The dietary supplement industry is largely self-regulated, which means product quality, ingredient transparency, and safety practices vary significantly between brands and products. The most reliable way to evaluate any supplement is to check for third-party testing certifications, review the full ingredient list and dosages, and research the brand's regulatory track record. GoodSupp's database of over 250,000 analyzed products provides independent quality scores, ingredient safety ratings, and brand trust reports to help you make evidence-based decisions.

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Disclaimer: GoodSupp provides independent supplement quality analysis for informational purposes only. Scores are generated algorithmically based on ingredient profiles, brand certifications, and public records. This is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Product data is sourced from manufacturer labels and public databases. GoodSupp is not affiliated with any supplement brand.