Propylene Glycol

Generally Safe SolventSynthetic

Propylene Glycol is a synthetic solvent used in dietary supplements. Safety rating: Generally Safe. It is generally considered safe for most people at standard doses. Found in 20 supplements in the GoodSupp database. Propylene glycol is a synthetic liquid used as a solvent and humectant.

20 Products use this
Generally Safe Safety rating
Solvent Category
No Natural origin

Safety Verdict: Generally Safe

Some individuals may be sensitive to propylene glycol.

What is Propylene Glycol?

Propylene glycol is a synthetic liquid used as a solvent and humectant.

Common Names Propylene Glycol, PG
Type Solvent
Origin Synthetic / Manufactured
Safety Rating Generally Safe

Why is Propylene Glycol used in supplements?

It is used as a solvent to dissolve ingredients.

Role in supplements: Solvent — dissolves or extracts active ingredients during manufacturing.

Should you be concerned about Propylene Glycol?

Generally no. Propylene Glycol is considered safe for most people at typical supplement doses. Some individuals may want to be aware of minor sensitivities.

Some individuals may be sensitive to propylene glycol.

Low risk. Generally safe for most people in supplement amounts.

Top-rated products containing Propylene Glycol

These 20 highest-scoring supplements in our database use Propylene Glycol.

Vital Proteins Collagen Gummies, Raspberry, 120 Gummies (0.625 g per Gummy)
Vital Proteins Collagen Gummies, Raspberry, 120 Gummies (0.625 g per Gummy)
Product 96 Brand N/A
Carlyle SAM-e 400mg
Carlyle SAM-e 400mg
Product 96 Brand N/A
Vitamineral B-12 Vitamin B-12 Liquid Supplement
Vitamineral B-12 Vitamin B-12 Liquid Supplement
Product 93 Brand N/A
Nature Made Fish Oil, Burp-Less, 1,000 mg, 150 Softgels
Nature Made Fish Oil, Burp-Less, 1,000 mg, 150 Softgels
Product 90 Brand N/A
Nature Made Burp-less Fish Oil 1000 mg
Nature Made Burp-less Fish Oil 1000 mg
Product 90 Brand N/A
GNC Vitamin D-3 50 mcg (2000 IU) Gummies
GNC Vitamin D-3 50 mcg (2000 IU) Gummies
Product 90 Brand N/A
Nature Made Burp-less Fish Oil 1000 mg
Nature Made Burp-less Fish Oil 1000 mg
Product 90 Brand N/A
Spring Valley Spring Valley - Vitamin E 400 IU, Water Soluble, 100 Softgels
Spring Valley Spring Valley - Vitamin E 400 IU, Water Soluble, 100 Softgels
Product 90 Brand N/A
Medix Select Antioxidant Multivitamin
Medix Select Antioxidant Multivitamin
Product 90 Brand N/A
Nature Made Digestive Probiotics Ultra-Strength Adult Gummies Raspberry & Cherry, 42 Gummies
Nature Made Digestive Probiotics Ultra-Strength Adult Gummies Raspberry & Cherry, 42 Gummies
Product 88 Brand N/A
The Vitamin Shoppe Allicin 6000 Garlic 650 mg
The Vitamin Shoppe Allicin 6000 Garlic 650 mg
Product 87 Brand N/A
The Vitamin Shoppe Allicin 6000 Garlic 650 mg
Product 87 Brand N/A
VitaFusion Vitafusion Power Zinc + C Gummy Vitamins - Helps Support Immune Function, Antioxidants, Healthy Hair, Skin, and Nails, 90 Count, 90 Vitamin Gummies
VitaFusion Vitafusion Power Zinc + C Gummy Vitamins - Helps Support Immune Function, Antioxidants, Healthy Hair, Skin, and Nails, 90 Count, 90 Vitamin Gummies
Product 87 Brand N/A
WAMPOLE Wampole Melatonin 10 mg Gummies – Maximum Strength – Helps Improve Sleep – Bonus Size – 100 gummies
WAMPOLE Wampole Melatonin 10 mg Gummies – Maximum Strength – Helps Improve Sleep – Bonus Size – 100 gummies
Product 87 Brand N/A
Almebex Plus Vitamin B12 Liquid
Almebex Plus Vitamin B12 Liquid
Product 87 Brand N/A
Reliable-1 Laboratories Liquid C 500 mg Orange Flavor
Reliable-1 Laboratories Liquid C 500 mg Orange Flavor
Product 83 Brand N/A
Health Star Vitamin C Liquid 500 mg Tasty Orange Flavor
Health Star Vitamin C Liquid 500 mg Tasty Orange Flavor
Product 83 Brand N/A
Sleep Soundly Liquid Melatonin 3.5 mg
Sleep Soundly Liquid Melatonin 3.5 mg
Product 83 Brand N/A
Nature Made Ultra Fish Oil 1400 mg
Nature Made Ultra Fish Oil 1400 mg
Product 83 Brand N/A
Nature Made Full Strength Mini Omega-3
Nature Made Full Strength Mini Omega-3
Product 83 Brand N/A
Related Ingredients
27% Alcohol Generally Safe 3-Butanediol Caution Alcohol Caution Alcohol Denat Caution Alcohol* Caution Alcohol Generally Safe Aloe Barbadensis (Aloe) Leaf Juice Generally Safe Aloe Barbadensis Leaf Juice* Generally Safe
Frequently Asked Questions
Is Propylene Glycol safe in supplements?

Propylene Glycol is rated generally safe for most people at amounts commonly found in supplements. While the overall safety profile is favorable, some individuals may experience minor sensitivities. Some individuals may be sensitive to propylene glycol. In GoodSupp's database, 20 products contain this ingredient. Consult your healthcare provider if you have specific concerns.

What is Propylene Glycol and why is it in my supplement?

Propylene glycol is a synthetic liquid used as a solvent and humectant. It appears in 20 products in the GoodSupp database.

Is Propylene Glycol natural or synthetic?

Propylene Glycol is synthetically produced, meaning it is manufactured through chemical processes rather than directly extracted from natural sources. Synthetic ingredients are extremely common in supplements and are not inherently less safe than natural alternatives. In many cases, synthetic production allows for higher purity and more consistent quality. The FDA regulates both natural and synthetic supplement ingredients under the same safety standards. GoodSupp rates ingredients based on their actual safety data regardless of whether they're natural or synthetic.

Check Any Supplement's Ingredients

Scan a barcode with GoodSupp to instantly see safety ratings for every ingredient.

Download on App Store
Disclaimer: GoodSupp provides independent supplement quality analysis for informational purposes only. Scores are generated algorithmically based on ingredient profiles, brand certifications, and public records. This is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Product data is sourced from manufacturer labels and public databases. GoodSupp is not affiliated with any supplement brand.