Polysorbate 80

Caution EmulsifierSynthetic

Polysorbate 80 is a synthetic emulsifier used in dietary supplements. Safety rating: Caution. Some individuals may want to exercise caution — consult a healthcare provider if concerned. Found in 20 supplements in the GoodSupp database. A synthetic emulsifier and surfactant.

20 Products use this
Caution Safety rating
Emulsifier Category
No Natural origin

Safety Verdict: Caution

Some studies suggest potential gut barrier disruption at high doses.

What is Polysorbate 80?

A synthetic emulsifier and surfactant.

Common Names Polysorbate 80, polysorbate,Tween 80,E433
Type Emulsifier
Origin Synthetic / Manufactured
Safety Rating Caution

Why is Polysorbate 80 used in supplements?

Helps mix oil and water-based ingredients.

Role in supplements: Emulsifier — helps blend ingredients that don't naturally mix (like oil and water) for uniform distribution.

Should you be concerned about Polysorbate 80?

Worth noting. Polysorbate 80 has some considerations that certain consumers should be aware of, though it is used widely in the supplement industry.

Some studies suggest potential gut barrier disruption at high doses.

Review recommended. Consider your individual health situation and consult a healthcare provider if concerned.

Top-rated products containing Polysorbate 80

These 20 highest-scoring supplements in our database use Polysorbate 80.

Carlson Vitamin A, 3,000 mcg RAE (10000 IU), 100 Soft Gels
Carlson Vitamin A, 3,000 mcg RAE (10000 IU), 100 Soft Gels
Product 96 Brand N/A
Swanson Q-Gel Mega 100, 100 mg, 60 Softgels
Swanson Q-Gel Mega 100, 100 mg, 60 Softgels
Product 96 Brand N/A
Carlson Vitamin A, 3,000 mcg RAE (10000 IU), 250 Soft Gels
Carlson Vitamin A, 3,000 mcg RAE (10000 IU), 250 Soft Gels
Product 96 Brand N/A
Cardiosmile 2000mg Plant Sterols 1400mg Beta-Sitosterols, 30 Liquid Sachets
Cardiosmile 2000mg Plant Sterols 1400mg Beta-Sitosterols, 30 Liquid Sachets
Product 96 Brand N/A
Pure Encapsulations Vitamin D3 VESIsorb
Pure Encapsulations Vitamin D3 VESIsorb
Product 96 Brand N/A
Nature's Bounty NATURE'S BOUNTY 5-HTP Time Released 200 mg, Helps to Promote Healthy Mood Balance, Helps Reduce Severity And Duration Of Migraines When Taken As A Preventative, Tablets 45.0 count, 45 Tablets
Nature's Bounty NATURE'S BOUNTY 5-HTP Time Released 200 mg, Helps to Promote Healthy Mood Balance, Helps Reduce Severity And Duration Of Migraines When Taken As A Preventative, Tablets 45.0 count, 45 Tablets
Product 96 Brand N/A
Jamieson Laboratories Jamieson Vitamin B12 (Methylcobalamin) 1,000 mg Fast Dissolving Strips, 30 strips
Jamieson Laboratories Jamieson Vitamin B12 (Methylcobalamin) 1,000 mg Fast Dissolving Strips, 30 strips
Product 96 Brand N/A
GNC Calcium Citrate 1000 mg
GNC Calcium Citrate 1000 mg
Product 95 Brand N/A
up&up Calcium + Vitamin D3 Tablets
up&up Calcium + Vitamin D3 Tablets
Product 92 Brand N/A
Nature Made Fish Oil, Burp-Less, 1,000 mg, 150 Softgels
Nature Made Fish Oil, Burp-Less, 1,000 mg, 150 Softgels
Product 90 Brand N/A
Health Thru Nutrition Hydrosoluble CoQ-10 as Q-Gel, 100 mg, 60 Softgels
Health Thru Nutrition Hydrosoluble CoQ-10 as Q-Gel, 100 mg, 60 Softgels
Product 90 Brand N/A
Nature Made Burp-less Fish Oil 1000 mg
Nature Made Burp-less Fish Oil 1000 mg
Product 90 Brand N/A
GNC Vitamin D-3 50 mcg (2000 IU) Gummies
GNC Vitamin D-3 50 mcg (2000 IU) Gummies
Product 90 Brand N/A
Nature Made Burp-less Fish Oil 1000 mg
Nature Made Burp-less Fish Oil 1000 mg
Product 90 Brand N/A
Country Life Mega CoQ10 100 mg
Country Life Mega CoQ10 100 mg
Product 90 Brand N/A
Spring Valley Spring Valley - Vitamin E 400 IU, Water Soluble, 100 Softgels
Spring Valley Spring Valley - Vitamin E 400 IU, Water Soluble, 100 Softgels
Product 90 Brand N/A
AvKARE Vitamin B-12 100mcg Tablets Energy & Nervous System Support
AvKARE Vitamin B-12 100mcg Tablets Energy & Nervous System Support
Product 88 Brand N/A
MVW COMPLETE FORMULATION MVW Complete Formulation D5000 Vitamin D3 Softgels 5000 IU for Bone, Immune
MVW COMPLETE FORMULATION MVW Complete Formulation D5000 Vitamin D3 Softgels 5000 IU for Bone, Immune
Product 87 Brand N/A
Qunol Ultra CoQ10, 100 mg, 120 Softgels
Qunol Ultra CoQ10, 100 mg, 120 Softgels
Product 83 Brand N/A
Qunol Ultra CoQ10, 200 mg, 60 Softgels
Qunol Ultra CoQ10, 200 mg, 60 Softgels
Product 83 Brand N/A
Related Ingredients
Frequently Asked Questions
Is Polysorbate 80 safe in supplements?

Polysorbate 80 carries a caution rating in supplements. While it is widely used in the industry, there are some considerations consumers should be aware of. This doesn't necessarily mean it's dangerous, but rather that certain populations (such as pregnant women, children, or people with specific health conditions) may want to exercise extra care. Some studies suggest potential gut barrier disruption at high doses. In GoodSupp's database, 20 products contain this ingredient. Consult your healthcare provider if you have specific concerns.

What is Polysorbate 80 and why is it in my supplement?

A synthetic emulsifier and surfactant. As an emulsifier, it helps blend ingredients that don't naturally mix (such as oil-based and water-based components) for uniform distribution. It appears in 20 products in the GoodSupp database.

Is Polysorbate 80 natural or synthetic?

Polysorbate 80 is synthetically produced, meaning it is manufactured through chemical processes rather than directly extracted from natural sources. Synthetic ingredients are extremely common in supplements and are not inherently less safe than natural alternatives. In many cases, synthetic production allows for higher purity and more consistent quality. The FDA regulates both natural and synthetic supplement ingredients under the same safety standards. GoodSupp rates ingredients based on their actual safety data regardless of whether they're natural or synthetic.

Check Any Supplement's Ingredients

Scan a barcode with GoodSupp to instantly see safety ratings for every ingredient.

Disclaimer: GoodSupp provides independent supplement quality analysis for informational purposes only. Scores are generated algorithmically based on ingredient profiles, brand certifications, and public records. This is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Product data is sourced from manufacturer labels and public databases. GoodSupp is not affiliated with any supplement brand.