Microcrystalline Cellulose

Safe FillerNatural

Microcrystalline Cellulose is a naturally derived filler used in dietary supplements. Safety rating: Safe. It is widely considered safe at typical supplement doses. Found in 20 supplements in the GoodSupp database. Refined wood pulp used as a bulking agent and filler.

20 Products use this
Safe Safety rating
Filler Category
Yes Natural origin

Safety Verdict: Safe

This ingredient is rated safe for use in dietary supplements.

What is Microcrystalline Cellulose?

Refined wood pulp used as a bulking agent and filler.

Common Names Microcrystalline Cellulose, MCC,cellulose
Type Filler
Origin Natural / Plant-derived
Safety Rating Safe

Why is Microcrystalline Cellulose used in supplements?

Adds bulk to small-dose supplements to make tablets/capsules a manageable size.

Role in supplements: Filler — adds bulk to fill capsules or tablets to a standard size. Does not contribute to the supplement's active benefits.

Should you be concerned about Microcrystalline Cellulose?

No. Microcrystalline Cellulose is widely regarded as safe for use in dietary supplements at typical levels. It has a long history of use and is accepted by major regulatory bodies.

No action needed. This ingredient is safe at amounts used in supplements.

Top-rated products containing Microcrystalline Cellulose

These 20 highest-scoring supplements in our database use Microcrystalline Cellulose.

Life Extension Lithium, 1,000 mcg, 100 Vegetarian Capsules
Life Extension Lithium, 1,000 mcg, 100 Vegetarian Capsules
Product 100 Brand N/A
Doctor's Best High Absorption Magnesium Lysinate Glycinate, Chelated, Albion® TRAACS®, 120 Tablets, (100 mg Per tablet)
Doctor's Best High Absorption Magnesium Lysinate Glycinate, Chelated, Albion® TRAACS®, 120 Tablets, (100 mg Per tablet)
Product 100 Brand N/A
California Gold Nutrition Biotin, 5,000 mcg, 30 Veggie Capsules
California Gold Nutrition Biotin, 5,000 mcg, 30 Veggie Capsules
Product 100 Brand N/A
California Gold Nutrition Women's Probiotics with Probiotic Bacteria Blend, Bifidobacterium lactis, Lactobacillus acidophilus, and Lactobacillus rhamnosus, 20 Billion CFU, 60 Veggie Capsules
California Gold Nutrition Women's Probiotics with Probiotic Bacteria Blend, Bifidobacterium lactis, Lactobacillus acidophilus, and Lactobacillus rhamnosus, 20 Billion CFU, 60 Veggie Capsules
Product 100 Brand N/A
California Gold Nutrition L-Theanine, Featuring AlphaWave, 100 mg, 30 Veggie Capsules
California Gold Nutrition L-Theanine, Featuring AlphaWave, 100 mg, 30 Veggie Capsules
Product 100 Brand N/A
Doctor's Best High Absorption Magnesium Lysinate Glycinate, Chelated, Albion® TRAACS®, 240 Tablets (100 mg Per tablet)
Doctor's Best High Absorption Magnesium Lysinate Glycinate, Chelated, Albion® TRAACS®, 240 Tablets (100 mg Per tablet)
Product 100 Brand N/A
California Gold Nutrition Beauty, Menopause Support with Angelica gigas, Cynanchum wilfordii, Phlomis umbrosa and L-Leucine, 30 Veggie Capsules
California Gold Nutrition Beauty, Menopause Support with Angelica gigas, Cynanchum wilfordii, Phlomis umbrosa and L-Leucine, 30 Veggie Capsules
Product 100 Brand N/A
California Gold Nutrition Selenium, Yeast-Free, 200 mcg, 180 Veggie Capsules
California Gold Nutrition Selenium, Yeast-Free, 200 mcg, 180 Veggie Capsules
Product 100 Brand N/A
Doctor's Best High Absorption Curcumin, 120 Veggie Caps
Doctor's Best High Absorption Curcumin, 120 Veggie Caps
Product 100 Brand N/A
California Gold Nutrition L-Glutathione (Reduced), 500 mg, 30 Veggie Capsules
California Gold Nutrition L-Glutathione (Reduced), 500 mg, 30 Veggie Capsules
Product 100 Brand N/A
NOW Foods NAC, 1,000 mg, 120 Tablets
NOW Foods NAC, 1,000 mg, 120 Tablets
Product 100 Brand N/A
California Gold Nutrition L-Glutathione (Reduced), 500 mg, 120 Veggie Capsules
California Gold Nutrition L-Glutathione (Reduced), 500 mg, 120 Veggie Capsules
Product 100 Brand N/A
NOW Foods Selenium, 100 mcg, 100 Tablets
NOW Foods Selenium, 100 mcg, 100 Tablets
Product 100 Brand N/A
Life Extension Super Selenium Complex & Vitamin E, 200 mcg, 100 Vegetarian Capsules
Life Extension Super Selenium Complex & Vitamin E, 200 mcg, 100 Vegetarian Capsules
Product 100 Brand N/A
NOW Foods Probiotic-10™ & Bifido Boost™, 90 Veg Capsules
NOW Foods Probiotic-10™ & Bifido Boost™, 90 Veg Capsules
Product 100 Brand N/A
California Gold Nutrition Acidophilus and Bifidus, Probiotic Blend with Lactobacillus acidophilus, Bifidobacterium lactis, and Bifidobacterium longum, 60 Veggie Capsules
California Gold Nutrition Acidophilus and Bifidus, Probiotic Blend with Lactobacillus acidophilus, Bifidobacterium lactis, and Bifidobacterium longum, 60 Veggie Capsules
Product 100 Brand N/A
Life Extension Vitamin B12, Methylcobalamin, 500 mcg, 100 Vegetarian Lozenges
Life Extension Vitamin B12, Methylcobalamin, 500 mcg, 100 Vegetarian Lozenges
Product 100 Brand N/A
Life Extension BioActive, Folate & Vitamin B12, 90 Vegetarian Capsules
Life Extension BioActive, Folate & Vitamin B12, 90 Vegetarian Capsules
Product 100 Brand N/A
NOW Foods Methyl B-12, 1,000 mcg, 100 Lozenges
NOW Foods Methyl B-12, 1,000 mcg, 100 Lozenges
Product 100 Brand N/A
NOW Foods Chewable Vitamin D-3, Fruit, 25 mcg (1000 IU), 180 Chewables
NOW Foods Chewable Vitamin D-3, Fruit, 25 mcg (1000 IU), 180 Chewables
Product 100 Brand N/A
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Frequently Asked Questions
Is Microcrystalline Cellulose safe in supplements?

Yes. Microcrystalline Cellulose is rated safe for use in dietary supplements at typical levels. This rating is based on regulatory assessments, published safety research, and its long history of use in the supplement industry. It is widely accepted by major regulatory bodies including the FDA and EFSA. In GoodSupp's database, 20 products contain this ingredient. Consult your healthcare provider if you have specific concerns.

What is Microcrystalline Cellulose and why is it in my supplement?

Refined wood pulp used as a bulking agent and filler. As a filler, it adds bulk to capsules or tablets to achieve a standard size without affecting the active ingredients. It appears in 20 products in the GoodSupp database.

Is Microcrystalline Cellulose natural or synthetic?

Microcrystalline Cellulose is naturally derived, meaning it comes from natural sources such as plants, minerals, or animal products rather than being chemically synthesized. Natural-origin ingredients are preferred by many consumers, though it's important to note that 'natural' does not automatically mean 'safer' — safety depends on the specific substance, its purity, and the amount used. The safety rating assigned by GoodSupp is based on the ingredient's actual safety profile, not its origin.

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Disclaimer: GoodSupp provides independent supplement quality analysis for informational purposes only. Scores are generated algorithmically based on ingredient profiles, brand certifications, and public records. This is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Product data is sourced from manufacturer labels and public databases. GoodSupp is not affiliated with any supplement brand.